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The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease

Corbin Laura J; Seppälä Ilkka; Raitoharju Emma; Kähönen Mika; Salmi Marko; Pitkänen Niina; Timpson Nicholas J; Salomaa Veikko; Kalaoja Marita; Havulinna Aki S; Lehtimäki Terho; Maksimow Mikael; Santalahti Kristiina; Ripatti Samuli; Raitakari Olli T; Lyytikäinen Leo-Pekka; Kettunen Johannes; Viikari Jorma S; Perola Markus; Jalkanen Sirpa; Ahola-Olli Ari V; Palotie Aarno; Tan Vanessa Y

Objective This study aimed to investigate the role of cytokines as intermediates in the pathway from increased adiposity to disease. Methods BMI and circulating levels of up to 41 cytokines ...

Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations

Bartz Traci M.; Braun Kim V.E.; Chasman Daniel I.; Dashti Hassan S.; Dupuis Josée; Forouhi Nita G.; Ghanbari Mohsen; Graff Mariaelisa; Guirette Melanie; Haslam Danielle E.; Helminen Mika; Herman Mark A.; Ikram M. Arfan; Imamura Fumiaki; Kiefte-de Jong Jessica C.; Kähönen Mika; Lehtimäki Terho; Lemaitre Rozenn N.; Li-Gao Ruifang; Lichtenstein Alice H.; Livingston Kara A.; Luan Jian’an; Manson JoAnn E.; Martin Lisa W.; McKeown Nicola M.; Meigs James B.; Merino Jordi; Mook-Kanamori Dennis O.; Mora Samia; Mossavar-Rahmani Yasmin; Mozaffarian Dariush; North Kari; Oddy Wendy H.; Peloso Gina M.; Pennell Craig E.; Pitkänen Niina; Pitsillides Achilleas N.; Psaty Bruce M.; Raitakari Olli T.; Rich Steven S.; Ridker Paul M.; Rosendall Frits R.; Rotter Jerome I.; Smith Caren E.; Snetselaar Linda; Taylor Kent D.; Tintle Nathan; Uitterlinden Andre G; Viikari Jorma S.; Voortman Trudy; Wang Carol A.; Wareham Nick J.; Westra Jason M.; Wood Alexis C.; Young Kristin L.; de Mutsert Renée

Background: ChREBP (carbohydrate responsive element binding protein) is a transcription factor that responds to sugar consumption. Sugar-sweetened beverage (SSB) consumption and genetic variants in the CHREBP locus ...

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The Role of Inflammatory Cytokines as Intermediates in the Pathway from Increased Adiposity to Disease

Sugar-Sweetened Beverage Consumption May Modify Associations Between Genetic Variants in the CHREBP (Carbohydrate Responsive Element Binding Protein) Locus and HDL-C (High-Density Lipoprotein Cholesterol) and Triglyceride Concentrations