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Cisplatin overcomes radiotherapy resistance in OCT4-expressing head and neck squamous cell carcinoma
<p><strong>Objectives: </strong>Cisplatin is combined with radiotherapy for advanced head and neck squamous cell carcinoma (HNSCC). While providing a beneficial effect on survival, it also causes side effects and thus is ...
Uusia työkaluja paikallisesti edenneen ja etäpesäkkeisen eturauhassyövän lääkehoitoon
<p>Eturauhassyöpä on miehillä tavallisimmin todettu syöpä ja miesten toiseksi yleisin syöpäkuolemien aiheuttaja Suomessa. Levinneen eturauhassyövän lääkehoidossa keskeistä on androgeenireseptorin toiminnan estäminen ...
Somatostatin receptor 2A in gliomas: Association with oligodendrogliomas and favourable outcome
Somatostatin receptor subtype 2A (SSTR2A) is a potential therapeutic target in gliomas. Data on SSTR2A expression in different glioma entities, however, is particularly conflicting. Our objective was to characterize SSTR2A ...
Expression of toll-like receptors in non-endemic nasopharyngeal carcinoma
<p>Background</p><p>Nasopharyngeal carcinoma (NPC) is a malignant disease with an enigmatic etiology. NPC associates with Epstein-Barr virus (EBV) and human papillomaviruses (HPVs), while immunological factors also play a ...
Radium-223 dichloride treatment in metastatic castration-resistant prostate cancer in Finland: A real-world evidence multicenter study
<p><strong>Background: </strong>Radium-233 dichloride is an alpha emitter that specifically targets bone metastases in prostate cancer. Results of a previously reported phase III randomized trial showed survival benefit ...