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Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study
<p><b>Background:</b>
Most survival data in colorectal cancer (CRC) is derived from clinical
trials or register-based studies. Hospital Biobanks, linked with
hospital electronic records, could serve as a data-gathering ...
Structural Basis for the Functional Changes by EGFR Exon 20 Insertion Mutations
<div><b>Simple Summary</b></div><div>Non-small cell lung cancer (NSCLC) is the most common type of lung cancer that claims the lives of many worldwide. Activating mutations occurring on the epidermal growth factor receptor ...
Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
Numerous somatic mutations occurring in the epidermal growth factor receptor (EGFR) family (ErbB) of receptor tyrosine kinases (RTK) have been reported from cancer patients, although relatively few have been tested and ...
EGFR gene copy number decreases during anti-EGFR antibody therapy in colorectal cancer
<p>Epidermal growth factor receptor (EGFR) gene copy number (GCN) increase is associated with a favorable anti-EGFR antibody treatment response in RAS wild-type metastatic colorectal cancer. However, there are limited and ...
SUMOylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the ErbB4 receptor tyrosine kinase
Erb-B2 receptor tyrosine kinase 4 (ErbB4) is a kinase that can signal via a proteolytically released intracellular domain (ICD) in addition to classical receptor tyrosine kinase-activated signaling cascades. Previously, ...
The guanine nucleotide exchange factor VAV3 participates in ERBB4-mediated cancer cell migration
ERBB4 is a member of the epidermal growth factor receptor (EGFR)/ERBB subfamily of receptor tyrosine kinases that regulates cellular processes including proliferation, migration, and survival. ERBB4 signaling is involved ...
Signaling pathways in human osteoclasts differentiation: ERK1/2 as a key player
<p>Little is known about the signaling pathways involved in the differentiation of human osteoclasts. The present study evaluated the roles of the Ras/PI3K/Akt/mTOR, Ras/Raf/MEK1/2/ERK1/2, calcium-PKC, and p38 signaling ...