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Breast cancer in neurofibromatosis type 1: overrepresentation of unfavourable prognostic factors
<div><h3>Abstract</h3><div><h4>BACKGROUND: </h4><p>An increased breast cancer incidence and poor survival have been reported for women with neurofibromatosis 1 (NF1). To explain the poor survival, we aimed to link the ...
The role of polygenic risk and susceptibility genes in breast cancer over the course of life
Polygenic risk scores (PRS) for breast cancer have potential to improve risk prediction, but there is limited information on their utility in various clinical situations. Here we show that among 122,978 women in the FinnGen ...
IL-6 and other biomarkers as predictors of severity in COVID-19
<p>Objective<br></p><p>Cytokine release syndrome is suggested to be the most important mechanism triggering acute respiratory distress syndrome and end organ damage in COVID-19. The severity of disease may be measured by ...
Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma
Protein-altering variants that are protective against human disease provide in vivo validation of therapeutic targets. Here we use genotyping data from UK Biobank (n = 337,151 unrelated White British individuals) and FinnGen ...
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species ...
Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study
<p><b>Background:</b>
Most survival data in colorectal cancer (CRC) is derived from clinical
trials or register-based studies. Hospital Biobanks, linked with
hospital electronic records, could serve as a data-gathering ...
Effects of Randomized Controlled Infancy-Onset Dietary Intervention on Leukocyte Telomere Length - The Special Turku Coronary Risk Factor Intervention Project (STRIP)
Reduced telomere length (TL) is a biological marker of aging. A high inter-individual variation in TL exists already in childhood, which is partly explained by genetics, but also by lifestyle factors. We examined the ...
FMNL2/FMNL3 formins are linked with oncogenic pathways and predict melanoma outcome
<p>While most early (stage I-II) melanomas are cured by surgery, recurrence
is not uncommon. Prognostication by current clinicopathological
parameters does not provide sufficient means for identifying patients
who ...