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Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
BackgroundReceptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or ...
Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study
<p><b>Background:</b>
Most survival data in colorectal cancer (CRC) is derived from clinical
trials or register-based studies. Hospital Biobanks, linked with
hospital electronic records, could serve as a data-gathering ...
Assessment of myocardial viability with [15O]water PET: A validation study in experimental myocardial infarction
<p>Background: Assessment of myocardial viability is often needed in patients with chest pain and reduced ejection fraction. We evaluated the performance of reduced resting MBF, perfusable tissue fraction (PTF), and ...
Validation of IMPROD biparametric MRI in men with clinically suspected prostate cancer: A prospective multi-institutional trial
<p>Background: Magnetic resonance imaging (MRI) combined with targeted biopsy (TB) is increasingly used in men with clinically suspected prostate cancer (PCa), but the long acquisition times, high costs, and inter-center/reader ...
[F-18]FDG Accumulation in Early Coronary Atherosclerotic Lesions in Pigs
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We found increased uptake of [F-18]FDG in coronary atherosclerotic lesions in a pig model. However, uptake in these early stage lesions was not detectable with in vivo PET imaging. Further studies are needed to clarify ...
Pegylated and liposomal doxorubicin is associated with high mortality and causes limited cardiotoxicity in mice
<p>Objective: We wanted to determine the impact of different doses of a pegylated and liposomal formulation of the cardiotoxic drug doxorubicin on cardiac function, fibrosis and survival in mice. The drug causes myocardial ...
Increased Expression and Altered Cellular Localization of Fibroblast Growth Factor Receptor-Like 1 (FGFRL1) Are Associated with Prostate Cancer Progression
Fibroblast growth factor receptors (FGFRs) 1-4 are involved in prostate cancer (PCa) regulation, but the role of FGFR-like 1 (FGFRL1) in PCa is unclear. FGFRL1 expression was studied by qRT-PCR and immunohistochemistry of ...
Accuracy of echocardiographic area-length method in chronic myocardial infarction: comparison with cardiac CT in pigs
Background: We evaluated echocardiographic area-length methods to measure left ventricle (LV) volumes and ejection fraction (EF) in parasternal short axis views in comparison with cardiac computed tomography (CT) in pigs ...
New prostate cancer grade grouping system predicts survival after radical prostatectomy
<p>Histological Gleason grading of <a title="Learn more about Prostate Cancer" href="https://www.sciencedirect.com/topics/medicine-and-dentistry/prostate-cancer"><u>prostate cancer</u></a> has been through modifications ...