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Mucosal-associated invariant T cell alterations during the development of human type 1 diabetes
Aims/hypothesis Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognise derivatives of bacterial riboflavin metabolites presented by MHC-Ib-related protein 1 (MR1) molecules and are important ...
Circulating CXCR5−PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes
<p>Aims/hypothesis Type 1 diabetes is preceded by a period of asymptomatic autoimmunity characterised by positivity for islet autoantibodies. Therefore, T helper cell responses that induce B cell activation are likely to ...
FOXP3+Regulatory T Cell Compartment Is Altered in Children With Newly Diagnosed Type 1 Diabetes but Not in Autoantibody-Positive at-Risk Children
The dysfunction of FOXP3-positive regulatory T cells (Tregs) plays a key role in the pathogenesis of autoimmune diseases, including type 1 diabetes (T1D). However, previous studies analyzing the peripheral blood Treg ...
Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes
<div><h4>AIMS/HYPOTHESIS: </h4><p>Enterovirus
infections have been associated with the development of type 1 diabetes
in multiple studies, but little is known about enterovirus-induced
responses in children at risk ...