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Arthroscopic Bankart versus open Latarjet as a primary operative treatment for traumatic anteroinferior instability in young males: a randomised controlled trial with 2-year follow-up
<p><strong>Objectives: </strong>To compare the success rates of arthroscopic Bankart and open Latarjet procedure in the treatment of traumatic shoulder instability in young males.</p><p><strong>Design: </strong>Multicentre ...
Effects of meal and incretins in the regulation of splanchnic blood flow
Objective: Meal ingestion is followed by a redistribution of blood flow (BF) within the splanchnic region contributing to nutrient absorption, insulin secretion and glucose disposal, but factors regulating this phenomenon ...
Operative versus conservative treatment of small, nontraumatic supraspinatus tears in patients older than 55 years: over 5-year follow-up of a randomized controlled trial
<div><h3>Background</h3><p>Nontraumatic <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/rotator-cuff" title="Learn more about rotator cuff from ScienceDirect's AI-generated Topic Pages">rotator cuff</a> tear is a common shoulder problem that can be treated either conservatively or operatively. In the previous publications of the 1- and 2-year results of this trial, we found no significant between-group clinical differences. The aim of this study was to investigate the differences in mid-term clinical and radiologic outcomes in patients older than 55 years.</p></div><div><h3>Materials and methods</h3><p>One hundred eighty shoulders with symptomatic, nontraumatic supraspinatus tears were randomly assigned to 1 of the 3 cumulatively designed treatment groups: physiotherapy (group 1); <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/acromioplasty" title="Learn more about acromioplasty from ScienceDirect's AI-generated Topic Pages">acromioplasty</a> and physiotherapy (group 2); and rotator cuff repair, acromioplasty, and physiotherapy (group 3). The change in the Constant score was the primary outcome measure. The secondary outcome measures were the change in the <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/visual-analog-scale" title="Learn more about visual analog scale from ScienceDirect's AI-generated Topic Pages">visual analog scale</a> score for pain and patient satisfaction. Radiologic analysis included evaluation of glenohumeral <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/osteoarthritis" title="Learn more about osteoarthritis from ScienceDirect's AI-generated Topic Pages">osteoarthritis</a> (OA) and <a href="https://www.sciencedirect.com/topics/medicine-and-dentistry/rotator-cuff-rupture" title="Learn more about rotator cuff tear from ScienceDirect's AI-generated Topic Pages">rotator cuff tear</a> arthropathy (CTA).<br></p><div><div><div><h3>Results</h3><p>A total of 150 shoulders (mean age, 71 years) were available for analysis after a mean follow-up period of 6.2 years. The mean sagittal tear size of the supraspinatus tendon tear at baseline was 10 mm in all groups (P = .33). During follow-up, 8 shoulders in group 1 and 2 shoulders in group 2 crossed over to rotator cuff repair. The mean baseline Constant score was 57.1, 58.2, and 58.7 in groups 1, 2, and 3, respectively (P = .85). There were no significant differences (P = .84) in the mean change in the Constant score: 18.5 in group 1, 17.9 in group 2, and 20.0 in group 3. There were no statistically significant differences in the change in the visual analog scale pain score (P = .74) and patient satisfaction (P = .83). At follow-up, there were no statistically significant differences in the mean progression of glenohumeral OA (P = .538) or CTA (P = .485) among the groups. However, the mean progression of glenohumeral OA from baseline to follow-up was statistically significant in the trial population (P = .0045).</p></div><div><h3>Conclusions</h3><p>On the basis of this study, operative treatment is no better than conservative treatment regarding small, nontraumatic, single-tendon supraspinatus tears in patients older than 55 years. Operative treatment does not protect against degeneration of the glenohumeral joint or CTA. Conservative treatment is a reasonable option for the primary initial treatment of these tears.</p></div></div></div><div><div><h2>Level of evidence</h2><div>Level II</div><div>Randomized Controlled Trial</div><div>Treatment Study</div></div><div><h2>Keywords</h2><div>Rotator cuff tear</div><div>conservative treatment</div><div>rotator cuff repair</div><div>Constant score</div><div>VAS pain score</div><div>patient satisfaction</div><div>radiographic analysis</div><div>randomized controlled trial</div></div></div> </div>...
Validation of IMPROD biparametric MRI in men with clinically suspected prostate cancer: A prospective multi-institutional trial
<p>Background: Magnetic resonance imaging (MRI) combined with targeted biopsy (TB) is increasingly used in men with clinically suspected prostate cancer (PCa), but the long acquisition times, high costs, and inter-center/reader ...
Preterm children's developmental coordination disorder, cognition and quality of life: a prospective cohort study
<div><p><strong>Objective</strong> To evaluate the rate of developmental coordination disorder (DCD) and its correlation to cognition and self-experienced health-related quality of life (HRQoL) in children born very ...
A Prospective Comparison of 18F-prostate-specific Membrane Antigen-1007 Positron Emission Tomography Computed Tomography, Whole-body 1.5 T Magnetic Resonance Imaging with Diffusion-weighted Imaging, and Single-photon Emission Computed Tomography/Computed Tomography with Traditional Imaging in Primary Distant Metastasis Staging of Prostate Cancer (PROSTAGE)
<p><strong>Background: </strong>Computed tomography (CT) and bone scintigraphy (BS) are the imaging modalities currently used for distant metastasis staging of prostate cancer (PCa).</p><p><strong>Objective: </strong>To ...
Individualised non-contrast MRI-based risk estimation and shared decision-making in men with a suspicion of prostate cancer: protocol for multicentre randomised controlled trial (multi-IMPROD V.2.0)
<p><b>Introduction</b> European Association of Urology and UK National Institute for Health and Care Excellence guidelines recommend that all men with suspicions of prostate cancer should undergo prebiopsy contrast enhanced, ...
Optimising the antibiotic treatment of uncomplicated acute appendicitis: a protocol for a multicentre randomised clinical trial (APPAC II trial)
<h3>Discussion</h3><p>To our knowledge, APPAC II trial is the first randomised controlled trial comparing per oral antibiotic monotherapy with intravenous antibiotic therapy continued by per oral antibiotics in the treatment ...
Comparison of reprojected bone SPECT/CT and planar bone scintigraphy for the detection of bone metastases in breast and prostate cancer
<p><strong>Objective: </strong>The aim of this study was to compare reprojected bone SPECT/CT (RBS) against planar bone scintigraphy (BS) in the detection of bone metastases in breast and prostate cancer patients.</p><p> ...
A randomised placebo-controlled double-blind multicentre trial comparing antibiotic therapy with placebo in the treatment of uncomplicated acute appendicitis: APPAC III trial study protocol
<div><p><strong>Introduction</strong> Recent studies show that antibiotic therapy is safe and feasible for CT-confirmed uncomplicated acute appendicitis. Spontaneous resolution of acute appendicitis has already been observed ...