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The impact of probiotic supplementation during pregnancy on DNA methylation of obesity-related genes in mothers and their children
<div><h3>Purpose</h3><p>Dietary
supplementation with probiotics during pregnancy has been suggested to
decrease the risk for obesity in women after delivery and to minimize
excessive weight gain in their children. ...
Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children
<p>Aims/hypothesis: During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy ...
Lapsen epäselvän sukupuolen diagnostiikka ja hoito
Kun vastasyntyneen sukupuolta ei pystytä heti tunnistamaan, häneltä tulee sulkea pois hengenvaarallinen lisämunuaisten vajaatoimintaan johtava virilisoiva lisämunuaishyperplasia ja tarvittaessa aloittaa siihen gluko- ja ...
Simulating Screening for Risk of Childhood Diabetes: The Collaborative Open Outcomes tooL (COOL)
<p>The Collaborative Open Outcomes tooL (COOL) is a novel, highly configurable application to simulate, evaluate and compare potential population-level screening schedules. Its first application is type 1 diabetes (T1D) ...
Influenza virus infections from 0 to 2 years of age: A birth cohort study
<p>Background/purpose: Influenza vaccine has been recommended in Finland since<br />2007 for all children of 6e35 months of age and in 2009 for those 6 months against pandemic<br />influenza. We investigated the incidence ...
Gut Microbiota and Serum Metabolome in Elite Cross-Country Skiers: A Controlled Study
Exercise has been shown to affect gut the microbiome and metabolic health, with athletes typically displaying a higher microbial diversity. However, research on the gut microbiota and systemic metabolism in elite athletes ...
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage
<p><b>Aims/hypothesis</b> Enteroviral infection has been implicated consistently as a key environmental factor correlating with the appearance of autoimmunity and/or the presence of overt type 1 diabetes, in which pancreatic ...
Retinoblastoma protein represses E2F3 to maintain Sertoli cell quiescence in mouse testis
<p>Maintenance of the differentiated state and cell cycle exit in adult
Sertoli cells depends on tumor suppressor retinoblastoma protein (RB,
also known as RB1). We have previously shown that RB interacts with
transcription factor E2F3 in the mouse testis. Here, we investigated how
E2f3 contributes to adult Sertoli cell proliferation in a mouse model of Sertoli cell-specific knockout of Rb by crossing these mice with an E2f3 knockout mouse line. In the presence of intact RB, E2f3 was redundant in Sertoli cells. However, in the absence of RB, E2f3 is a key driver for cell cycle re-entry and loss of function in adult Sertoli cells. Knockout of E2f3 in Sertoli cells rescued the breakdown of Sertoli cell function associated with Rb
loss, prevented proliferation of adult Sertoli cells and restored
fertility of the mice. In summary, our results show that RB-mediated
repression of E2F3 is critical for the maintenance of cell cycle exit
and terminal differentiation in adult mouse Sertoli cells.</p>...
Pubarche and Gonadarche Onset and Progression Are Differently Associated With Birth Weight and Infancy Growth Patterns
<p>Context: Controversy exists regarding associations between early-life growth patterns and timing of puberty.<br></p><p>Objective: This work aims to investigate associations between birth anthropometry, early growth ...
Maternal Pregnancy-Related Anxiety Is Associated With Sexually Dimorphic Alterations in Amygdala Volume in 4-Year-Old Children
Prenatal stress is associated with child behavioral outcomes increasing susceptibility for psychiatric disorders in later life. Altered fetal brain development might partly mediate this association, as some studies suggest. ...