Hae

<p><strong>Background and Objectives</strong> Serum creatinine is typically used to assess kidney function. Impaired kidney function and thus high serum creatinine increase the risk of poor cognitive performance. However, ...

<p>Aim<br></p><p>We aimed at identifying the shared biological processes underlying atherosclerosis-osteoporosis co/multimorbidity.</p><p>Methods</p><p>We performed gene set analysis (GSA) of whole-blood transcriptomic ...

<p>Background</p><p>Non-coding RNA 886 (nc886) is coded from a maternally inherited metastable epiallele. We set out to investigate the determinants and dynamics of the methylation pattern at the nc886 epiallele and how ...

<p><strong>Background: </strong>The links between fatty acids (FAs) and cardiometabolic outcomes are topics of debate.</p><p><strong>Objective: </strong>Our aim was to investigate the associations between serum standardized ...

<p>INTRODUCTION</p><p>The role of risk factor profile in childhood and adolescence on adulthood cognitive function and whether it differs by genetic risk is still obscure. To bring this evidence, we determined cognitive ...

<p><strong>Objective: </strong>To evaluate the association between childhood parental smoking exposure and the risk of overweight/obesity from childhood to adulthood.</p><p><strong>Methods: </strong>This study leverages ...

<p>Objective<br></p><p>Oxidation of low-density lipoprotein (LDL) may promote atherosclerosis, whereas the reverse transport of oxidized lipids by high-density lipoprotein (HDL) may contribute to atheroprotection. To provide ...

<p>Background<br></p><p>Increased left ventricular mass (LVM) predicts cardiovascular events and mortality. The objective of this study was to determine whether early-life exposures to body mass index (BMI) and systolic blood pressure (SPB) affects the left ventricular structure in adulthood.<br></p><p>Methods<br></p><p>We used longitudinal data from a 31-year follow-up to examine the associations between early-life (between ages 6-18) BMI and SPB on LVM in an adult population (N = 1864, aged 34-49). The burden of early-life BMI and SBP was defined as area under the curve.<br></p><p>Results<br></p><p>After accounting for contemporary adult determinants of LVM, early-life BMI burden associated significantly with LVM (3.61 g/SD increase in early-life BMI; [1.94 - 5.28], p < 0.001). Overweight in early-life (age- and sex-specific BMI values corresponding to adult BMI > 25 kg/m²) associated with 4.7% (2.5-6.9%, p < 0.0001) higher LVM regardless of BMI status in adulthood. Overweight in early-life combined with obesity in adulthood (BMI > 30kg/m²) resulted in a 21% (17.3-32.9%, p < 0.0001) increase in LVM. Higher early-life BMI was associated with a risk of developing eccentric hypertrophy. The burden of early-life SPB was not associated with adult LVM or left ventricular remodeling.<br></p><p>Conclusions<br></p><p>High BMI in early-life confers a sustained effect on LVM and the risk for eccentric hypertrophy independently of adulthood risk factors.</p>...

We analysed whole blood genome-wide expression data to identify gene co-expression modules shared by early traits of osteoporosis and atherosclerosis. Gene expression was profiled for the Young Finns Study participants. ...

<b>Background: </b>Cardiovascular risk factors, such as high blood pressure, adverse serum lipids, and elevated body mass index in midlife, may harm cognitive performance. It is important to note that longitudinal accumulation ...