Hae
Aineistot 21-25 / 25
HLA-DR-DQ haplotypes and specificity of the initial autoantibody in islet specific autoimmunity
<p>Objective<br>We aimed to clarify the association of various HLA risk alleles with different types of autoantibodies initiating islet specific autoimmunity.</p><p>Methods<br>Follow-up cohorts from the Finnish Type 1 ...
Determining the timing of pubertal onset via a multicohort analysis of growth
<p><strong>Objective</strong></p><p>Growth-based determination of pubertal onset timing would be cheap and practical. We aimed to determine this timing based on pubertal growth markers. Secondary aims were to estimate the ...
Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage
<p><b>Aims/hypothesis</b> Enteroviral infection has been implicated consistently as a key environmental factor correlating with the appearance of autoimmunity and/or the presence of overt type 1 diabetes, in which pancreatic ...
Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes
<p>Objectives We aimed to further characterize demography and genetic associations of type 1 diabetes "endotypes" defined by the first appearing islet specific autoantibodies. Research Design and Methods We analyzed 3277 ...
Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children
<p>Background <br></p><p>Decreased exposure to microbial agents in industrialized countries and urban living areas is considered as a risk factor of developing immune-mediated diseases, such as allergies and asthma. ...