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Therapeutic Potential of Targeting the SUMO Pathway in Cancer
<p> The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery components have been observed in human cancer. Due ...
Sex-Dependent Improvement in Survival of Parkinson's Disease Patients
Background Advances in the treatment of Parkinson's disease (PD) and changes in general life expectancy may have improved survival in patients with PD.Objective The objective of this study was to investigate recent trends ...
Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1
<p>Rosette-forming glioneuronal tumor (RGNT) is a rare brain neoplasm that primarily affects young adults. Although alterations affecting the mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K) ...
Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
BackgroundReceptor tyrosine kinases (RTK) are potential targets for the treatment of ischemic heart disease. The human RTK family consists of 55 members, most of which have not yet been characterized for expression or ...
Persistent human bocavirus 1 infection and tonsillar immune responses
<p><b>Background</b> Persistent human bocavirus 1 (HBoV1) infection is a common finding in patients suffering from chronic tonsillar disease. However, the associations between HBoV1 infection and specific immune reactions ...
Brain volumes in relation to loneliness and social competence in preadolescents born very preterm
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<h3> Introduction</h3>
<p>The aim of the present study was to assess how
regional brain volumes associate ...
Koronainfektion laboratoriodiagnostiikka: Miten laboratorio valitsee menetelmät?
<p>Laboratoriot valitsevat käyttöönsä testit käyttötarkoituksen ja soveltuvuuden perusteella siten, että diagnostiikka on mahdollisimman vaikuttavaa. PCR on luotettavin koronavirustartunnan toteamiseen, mutta etenkin ...
Tumor Profile and Neuropsychological Symptoms of a Family with Novel Pathogenic Variant in NF1 Found by an RNA-Based Analysis
<p>Neurofibromatosis 1 (NF1) is a hereditary monogenic disorder. Common symptoms are cafe au lait spots and / or axillary or inguinal freckles, and cutaneous neurofibromas. In a recent population-based study the cancer ...
Cisplatin overcomes radiotherapy resistance in OCT4-expressing head and neck squamous cell carcinoma
<p><strong>Objectives: </strong>Cisplatin is combined with radiotherapy for advanced head and neck squamous cell carcinoma (HNSCC). While providing a beneficial effect on survival, it also causes side effects and thus is ...