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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
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Genome-wide association studies (GWAS) have identified more than 100 genetic variants contributing to BMI, a measure of body size, or waist-to-hip ratio (adjusted for BMI, WHRadjBMI), a measure of body shape. Body ...
Modular genome-wide gene expression architecture shared by early traits of osteoporosis and atherosclerosis in the Young Finns Study
We analysed whole blood genome-wide expression data to identify gene co-expression modules shared by early traits of osteoporosis and atherosclerosis. Gene expression was profiled for the Young Finns Study participants. ...
Afamin predicts the prevalence and incidence of nonalcoholic fatty liver disease
<p>Objectives<br>In the general population, increased afamin concentrations are associated with the prevalence and incidence of metabolic syndrome as well as type 2 diabetes. Although metabolic syndrome is commonly associated ...
Dietary Saturated Fat and Bone Health in Young Adults: The Young Finns Cohort
Previous studies suggest that saturated fat (SFA) intake may negatively impact on bone. However, few human studies on the topic exist. Women and men aged 31-46 years from the Cardiovascular Risk in Young Finns study attended ...
Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium
<p><b>Background: </b>In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce. ...
Fatal traumatic brain injuries during 13 years of successive alcohol tax increases in Finland - a nationwide population-based registry study
We sought to investigate how increases in alcohol taxation and changes in alcohol consumption were associated with the incidence rate of fatal traumatic brain injuries (TBI) in Finland during the years 2004-2016. Nationwide, ...
Impaired long-term outcomes of patients with schizophrenia spectrum disorder after coronary artery bypass surgery: nationwide case-control study
<p><strong>Background: </strong>Patients with schizophrenia spectrum disorder have increased risk of coronary artery disease.</p><p><strong>Aims: </strong>To investigate long-term outcomes of patients with schizophrenia ...
Associations of long-term solar insolation with specific depressive symptoms: Evidence from a prospective cohort study
<p>Evidence suggests that sunlight counteracts depression, but the associations of long-term sunlight exposure with specific symptoms of depression are not well known. We evaluated symptom-specific associations of average ...
Schizophrenia polygenic risk score and long-term success in the labour market: A cohort study
Employment is rare among people with a schizophrenia diagnosis. Meanwhile, a genetic liability for schizophrenia may hinder labour market performance. We studied how the polygenic risk score (PGS) for schizophrenia related ...
Long-term cardiovascular prognosis of patients with type 1 diabetes after myocardial infarction
<p>Background<br>To explore long-term cardiovascular prognosis after myocardial infarction (MI) among patients with type 1 diabetes.</p><p>Methods<br>Patients with type 1 diabetes surviving 90 days after MI (n = 1508; 60% ...