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Aineistot 31-40 / 52

Meta-analysis of exome array data identifies six novel genetic loci for lung function

Heckbert SR; Johansson Å; Raitakari OT; Justesen JM; Campbell A; Latourelle JC; Pottinger TD; Lohman K; Stubbe B; Understanding Society Scientific Group; Brody JA; Hansen T; Vestergaard H; Loukola A; Barr RG; Psaty BM; Morrison AC; Burkart KM; Cassano PA; Kraja A; Karrasch S; Hayward C; Harris TB; Strauch K; Smith AV; Manichaikul A; Teumer A; Schulz H; Morris AP; Uitterlinden AG; Wyss AB; Lehtimäki T; Ingelsson E; Gyllensten U; Mahajan A; Deary IJ; Altmaier E; Province MA; Pisinger C; Taylor KD; Porteous DJ; Lind L; Huffman JE; Hall IP; Gao W; Sin DD; Mook-Kanamori DO; Qaiser B; Gläser S; Imboden M; Polasek O; Brusselle GG; Li-Gao R; Jackson VE; Bossé Y; Smith BH; Gudnason V; Mychaleckyj JC; Kerr S; Tang W; Bonten TN; North KE; Prins B; Weiss S; Liu Y; Lyytikäinen LP; Linneberg A; Kähönen M; Probst-Hensch N; Sitlani CM; Wilson JG; Lind-Thomsen A; de Mutsert R; Rich SS; Bork-Jensen J; Dupuis J; Zeggini E; Enroth S; Strachan DP; Franceschini N; Rawal R; Skaaby T; Rantanen T; Kritchevsky SB; O'Connor GT; Lahousse L; London SJ; Wain LV; Bartz TM; Hao K; Harris SE; Lange LA; Marten J; Kaprio J; Obeidat M; Kumar A; Eiriksdottir G; Timens W; Tobin MD; Ikram MA; Davies G; Pederson O; Ahluwalia TS; Li J; Grarup N; Starr JM; Grove ML; Gharib SA

Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of ...

Genome-Wide Meta-Analysis of Sciatica in Finnish Population

Lemmela S; Kettunen J; Husgafvel-Pursiainen K; Heliovaara M; Solovieva S; Viikari J; Perola M; Shiri R; Ripatti S; Raitakari OT; Anttila V; Juonala M; Kahonen M; Benner C; Salomaa V; Palotie A; Seppala I; Viikari-Juntura E; Lehtimaki T

Sciatica or the sciatic syndrome is a common and often disabling low back disorder in the working-age population. It has a relatively high heritability but poorly understood molecular mechanisms. The Finnish population is ...

Discovery of novel heart rate-associated loci using the Exome Chip

Hagemeijer Y; Guo XQ; Rosand J; Psaty BM; Grarup N; Taylor KD; Pistis G; Shah N; Cabrera CP; Hayward C; Rudan I; Lin HH; Eppinga RN; Mangino M; Prins BP; Hall LM; Porteous DJ; Mook-Kanamori DO; Asselbergs FW; Deloukas P; Wilson J; Roselli C; Harris TB; Qi LH; Eijgelsheim M; Li M; Soliman EZ; Arking DE; Doney ASF; Caulfield MJ; Padmanabhan S; Yao J; Stirrups KE; Kääb S; Jukema JW; Marten J; Xie ZJ; de Mutsert R; Sotoodehnia N; Li-Gao RF; Isaacs A; Gudnason V; Sinner MF; Kooperberg C; Völker U; O'Donnell CJ; Jamshidi Y; Samani NJ; Kanters JK; Uitterlinden A; Murray AD; Pedersen O; Morris AD; Raitakari OT; Fu YP; Sanna S; Ellinor PT; Kors JA; Mifsud B; Dedoussis G; van Duijn CM; Zoledziewska M; Hoes AW; Waldenberger M; Tobin MD; Spector TD; van der Meer P; de Haan HG; Felix SB; Palmer CNA; Müller-Nurasyid M; Silva CT; Launer LJ; Sattar N; Lin HJ; Haessler J; Peters A; Lehtimäki T; Stanton AV; Mulas A; Bihlmeyer NA; Kolcic I; Lubitz SA; Trompet S; Tinker A; van der Harst P; Brody JA; Sever P; van den Berg ME; Poulter N; Lyytikainen LP; Rotter JI; Hwang SJ; Macfarlane PW; Stricker BH; Zeggini E; Munroe PB; de Boer R; Verweij N; Dörr M; Rivadeneira F; Hansen T; Weiss S; Vaartjes I; Heckbert SR; Liu SM; Mei H; Radmanesh F; Alonso A; van Setten J; Orrú M; Entwistle A; Nelson CP; Smith AV; Dominiczak AF; Linneberg A; Polasek O; Warren HR; Bis JC; Huang PL; Kähönen M

Resting heart rate is a heritable trait, and an increase in heart rate is associated with increased mortality risk. Genome-wide association study analyses have found loci associated with resting heart rate, at the time of ...

CNV-association meta-analysis in 191,161 European adults reveals new loci associated with anthropometric traits

Cusi D; Franke L; Noukas M; Raitakari OT; Perola M; Kutalik Z; Sinisalo J; Reymond A; Koponen P; Loos RJF; Sapkota Y; Yaghootkar H; Oldehinkel AJ; Geller F; Lokki ML; Metspalu A; Chambers JC; Porcu E; Nolte IM; Wain LV; Jacquemont S; Strachan DP; Sparso T; Ang WQ; Kahonen M; Feitosa MF; Perls TT; Wood AR; Mannik K; Lundqvist A; Rissanen H; Salvi E; Snieder H; Palotie A; Bottinger EP; Venturini C; Lehtimaki T; Beaumont RN; Koskinen S; Wray NR; Hirschhorn J; Kriebel J; Mannisto S; Heid IM; Werge T; Shrine N; Hansen TF; Meitinger T; Beckmann JS; Lettre G; Schick U; Peters A; Deloukas P; Ruth KS; Newman AB; Wojczynski MK; Boers H; Lenzini P; Frayling TM; Nieminen M; Afaq S; Liu XP; Martin NG; Medland SE; Tyrrell J; Kristiansson K; Melbye M; Mattsson H; Christensen K; Porteous D; Feenstra B; Kooner JS; Muller-Nurasyid M; Magi R; Deelen P; Freathy RM; van der Most PJ; Salomaa V; Hayward C; Viikari JS; Schupf N; Nyholt DR; Winkler TW; Jones SE; Zhang WH; Spector TD; Havulinna AS; Lahti J; Bochud M; Eriksson JG; Rueger S; Province MA; Tobin MD; Weedon MN; Rivadeneira F; Vartiainen E; Tuke MA; Mangino M; Swertz MA; McDaid AF; Montgomery GW; Murray A; Rosengren A; Pennell C; Borodulin K; Mace A

There are few examples of robust associations between rare copy number variants (CNVs) and complex continuous human traits. Here we present a large-scale CNV association meta-analysis on anthropometric traits in up to ...

Determinants of left ventricular diastolic function-The Cardiovascular Risk in Young Finns Study

Kähönen M; Rovio SP; Hutri-Kähonen N; Viikari JSA; Juonala M; Raitakari OT; Heiskanen JS; Tossavainen P; Laitinen T; Lehtimäki T; Jokinen E; Kytö V; Ruohonen S

Decreased left ventricular (LV) diastolic function is associated with increased all-cause mortality and risk for a heart failure. The determinants of LV diastolic function have been mainly studied in elderly populations; ...

Exposure to parental smoking and cardiac structure and function in adulthood: the Cardiovascular Risk in Young Finns Study

Ruohonen S; Pahkala K; Magnussen CG; Burgner DP; Laitinen TP; Tossavainen P; Kahonen M; Nuotio J; Taittonen L; Pihlman J; Jokinen E; Hutri-Kahonen N; Rovio S; Raitakari OT; Viikari JSA; Juonala M

Background and aims: The relationship between childhood tobacco smoke exposure and cardiac structure and function in midlife is unclear. We investigated the association between parental smoking with ...

PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity

Polasek O; Arnar DO; Tarasov KV; Boerwinkle E; Samani NJ; Pramstaller PP; Lin HJ; Butler AM; Avery CL; Ulivi S; Trompet S; Parsa A; de Bakker PIW; Macfarlane PW; Verweij N; Ritchie MD; Lin HH; Hayward C; Krijthe BP; Volzke H; Lyytikainen LP; Spector TD; Heckbert SR; Ehret GB; Barnard J; Soliman EZ; Gharib SA; Strauch K; Gasparini P; Sinagra G; Hicks AA; Munzel T; Felix SB; Bis J; Eijgelsheim M; Asselbergs FW; Roden DM; Kerr KF; Rudan I; Psaty BM; Benjamin EJ; Gudbjartsson DF; Snieder H; Liu YM; Wilson JF; Thorsteinsdottir U; Waldenberger M; Stricker BH; Teumer A; Schnabel RB; Muller-Nurasyid M; Buckley BM; van der Harst P; Steri M; Jukema JW; Alonso A; Loos RJF; Lehtimaki T; Smith AV; Campbell H; Pfeufer A; Nolte IM; Westra HJ; Jamshidi Y; Padmanabhan S; Yin XY; Mitchell BD; Uitterlinden AG; Arking DE; Sinner MF; Van Wagoner DR; Ferrucci L; Lubitz SA; Bradford Y; Aldana CTS; Launer LJ; van Setten J; Magnani JW; Isaacs A; Crawford D; Cucca F; Volker U; Ilaria G; Dorr M; Raitakari OT; Peters A; Gudnason V; Lakatta EG; Evans DS; Swenson BR; Zeller T; Stott DJ; Papanicolaou GJ; Kors JA; Schlessinger D; Del Greco FM; Munroe PB; Leach IM; Kaab S; Gibson Q; Bandinelli S; Blankenberg S; Kahonen M; Robino A; Brody JA; Dominiczak AF; den Hoed M; Wild PS; Sotoodehnia N; Holm H; van Duijn CM; Stefansson K; Harris TB; Bader JS; Iorio A; Tanaka T; Franke L; Rotter JI; Meitinger T; Denny JC; Smith JD; Muller C; Chung MK; Franco OH; Kolcic I; Ellinor PT

Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genomewide association study of over 92,000 ...

Tracking and Changes in Daily Step Counts among Finnish Adults

Rovio SP; Hirvensalo M; Tammelin TH; Pahkala K; Hakonen H; Raitakari OT; Kulmala J; Hutri-Kahonen N; Yang XL; Kukko T

Purpose This study aimed to investigate the tracking and changes of steps per day in adults and their determinants over 13 yr. Methods A total of 2195 subjects (1236 women) 30-45 yr of age were randomly recruited from the ...

Exposure to Parental Smoking in Childhood is Associated with High C-Reactive Protein in Adulthood: The Cardiovascular Risk in Young Finns Study

Viikari JSA; Wang D; Raitakari OT; Juonala M; Magnussen CG; Wu F; Hutri-Kähönen N

Aim: Children exposed to parental smoking are at increased long-term risk of subclinical atherosclerosis in adulthood. However, it has not been quantified if exposure to parental smoking in childhood is ...

Lipoprotein signatures of cholesteryl ester transfer protein and HMG-CoA reductase inhibition

Tillin T; Di Angelantonio E; Oliver-Williams C; Salomaa V; Anufrieva O; Ohukainen P; Kähönen M; Viikari J; Ala-Korpela M; Raitakari OT; Hughes AD; Holmes MV; Kettunen J; Järvelin MR; Perola M; Wang Q; Davey Smith G; Allara E; Chaturvedi N; Lehtimäki T; Danesh J; Butterworth AS

Cholesteryl ester transfer protein (CETP) inhibition reduces vascular event risk, but confusion surrounds its effects on low-density lipoprotein (LDL) cholesterol. Here, we clarify associations of genetic inhibition ...