Hae
Aineistot 31-40 / 403
Efficient Binding of the NOS1AP C-Terminus to the nNOS PDZ Pocket Requires the Concerted Action of the PDZ Ligand Motif, the Internal ExF Site and Structural Integrity of an Independent Element
Neuronal nitric oxide synthase is widely regarded as an important contributor to a number of disorders of excitable tissues. Recently the adaptor protein NOS1AP has emerged as a contributor to several nNOS-linked conditions. ...
A multiscale framework for evaluating three-dimensional cell mechanics in fibril-reinforced poroelastic tissues with anatomical cell distribution – Analysis of chondrocyte deformation behavior in mechanically loaded articular cartilage
Characterization of the mechanical environment of cells in collagenous biological tissues during different daily activities is crucial for understanding the role of mechanics on cell biosynthesis and tissue health. However, ...
Transcytosis route mediates rapid delivery of intact antibodies to draining lymph nodes
<p>Lymph nodes (LNs) filter lymph to mount effective immune responses. Small soluble lymph-borne molecules from the periphery enter the draining LNs via a reticular conduit system. Intact antibodies and other larger ...
Glycomic and Glycoproteomic Techniques in Neurodegenerative Disorders and Neurotrauma: Towards Personalized Markers
The proteome represents all the proteins expressed by a genome, a cell, a tissue, or an organism at any given time under defined physiological or pathological circumstances. Proteomic analysis has provided unparalleled ...
Expression Atlas: gene and protein expression across multiple studies and organisms
Expression Atlas (http://www.ebi.ac.uk/gxa) is an added value database that provides information about gene and protein expression in different species and contexts, such as tissue, developmental stage, disease or cell ...
Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life
<p><b>Background:</b> Current evidence suggests that the composition of infant formula (IF) affects the gut microbiome, intestinal function, and immune responses during infancy. However, the impact of IF on circulating ...
snpEnrichR: analyzing co-localization of SNPs and their proxies in genomic regions
<h4>Motivation: </h4><p>Co-localization of trait associated SNPs for
specific transcription-factor binding sites or regulatory regions in the
genome can yield profound insight into underlying causal mechanisms.
Analysis ...
Differential ATAC-seq and ChIP-seq peak detection using ROTS
<p> Changes in cellular chromatin states fine-tune transcriptional output and ultimately lead to phenotypic changes. Here we propose a novel application of our reproducibility-optimized test statistics (ROTS) to detect ...