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A variation in the infant oxytocin receptor gene modulates infant hippocampal volumes in association with sex and prenatal maternal anxiety
Genetic variants in the oxytocin receptor (OTR) have been linked to distinct social phenotypes, psychiatric disorders and brain volume alterations in adults. However, to date, it is unknown how OTR genotype shapes prenatal ...
Sukupuolen kehityksen biologia ja genetiikka
Sukurauhanen kehittyy kivekseksi tai munasarjaksi kahden toisilleen vastakkaisen signaalireitin ohjaamana. Y-kromosomissa sijaitseva SRY-geeni käynnistää kiveksen kehityksen, minkä jälkeen miehen sukuelinten kehitys on ...
HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children
<p><b>Objective </b><br>Increased level of glycated hemoglobin (HbA1c) is associated with type 1 diabetes onset that in turn is preceded by one to several autoantibodies against the pancreatic islet beta cell autoantigens; ...
Reproductive Markers of Testicular Function and Size During Puberty in Boys With and Without a History of Cryptorchidism
<p><b>Context</b><br></p><p>Longitudinal data on levels of hypothalamic-pituitary-gonadal axis hormones and insulin-like growth factor I (IGF-I) during puberty in boys with a history of cryptorchidism are largely ...
Quantifying the utility of islet autoantibody levels in the prediction of type 1 diabetes in children
<p><strong>Aims/hypothesis: </strong>The aim of this study was to explore the utility of islet autoantibody (IAb) levels for the prediction of type 1 diabetes in autoantibody-positive children.</p><p><strong>Methods: </s ...
European academy of andrology guidelines on Klinefelter Syndrome: Endorsing Organization: European Society of Endocrinology
Background Knowledge about Klinefelter syndrome (KS) has increased substantially since its first description almost 80 years ago. A variety of treatment options concerning the spectrum of symptoms associated with KS exists, ...
Association of Cumulative Paternal Early Life Stress With White Matter Maturation in Newborns
This cohort study examines infants and parents in the FinnBrain Birth Cohort to assess the association between paternal cumulative early life stress and offspring brain development.Question Is there an association between ...
Retinoblastoma-E2F Transcription Factor Interplay Is Essential for Testicular Development and Male Fertility
<p>The retinoblastoma (RB) protein family members (pRB, p107 and p130) are key regulators of cell cycle progression, but also play crucial roles in apoptosis, and stem cell self-renewal and differentiation. RB proteins ...
Sex-specific associations between maternal pregnancy-specific anxiety and newborn amygdalar volumes-preliminary findings from the FinnBrain Birth Cohort Study
Previous literature links maternal pregnancy-specific anxiety (PSA) with later difficulties in child emotional and social cognition as well as memory, functions closely related to the amygdala and the hippocampus. Some ...