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Aineistot 41-50 / 403
SimPhospho: a software tool enabling confident phosphosite assignment
Motivation: Mass spectrometry combined with enrichment strategies for phosphorylated peptides has been successfully employed for two decades to identify sites of phosphorylation. However, unambiguous phosphosite assignment ...
Compressive stress-mediated p38 activation required for ERα + phenotype in breast cancer
<p>Breast cancer is now globally the most frequent cancer and leading cause of women's death. Two thirds of breast cancers express the luminal estrogen receptor-positive (ER alpha + ) phenotype that is initially responsive ...
Maximum shear strain-based algorithm can predict proteoglycan loss in damaged articular cartilage
<p>Post-traumatic osteoarthritis (PTOA) is a common disease, where the mechanical integrity of articular cartilage is compromised. PTOA can be a result of chondral defects formed due to injurious loading. One of the first ...
Lipidome as a predictive tool in progression to type 2 diabetes in Finnish men
Background. There is a need for early markers to track and predict the development of type 2 diabetes mellitus (T2DM) from the state of normal glucose tolerance through prediabetes. In this study we tested whether the ...
Protein synthesis is suppressed in sporadic and familial Parkinson's disease by LRRK2
Gain of function LRRK2-G2019S is the most frequent mutation found in familial and sporadic Parkinson's disease. It is expected therefore that understanding the cellular function of LRRK2 will provide insight on the ...
Early suppression of immune response pathways characterizes children with prediabetes in genome-wide gene expression profiling
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Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing pancreatic p cells in the islets of Langerhans. Although defects in various T cell subsets have been linked to the disease pathogenesis, ...
CRISPR/Cas9 guided genome and epigenome engineering and its therapeutic applications in immune mediated diseases
<p>Recent developments in the nucleic acid editing technologies have provided a powerful tool to precisely engineer the genome and epigenome for studying many aspects of immune cell differentiation and development as well ...
Mechano-responsiveness of fibrillar adhesions on stiffness-gradient gels
Fibrillar adhesions are important structural and adhesive components in fibroblasts, and are required for fibronectin fibrillogenesis. While nascent and focal adhesions are known to respond to mechanical cues, the ...
Rho mediates calcium-dependent activation of p38 alpha and subsequent excitotoxic cell death
Excitotoxic neuronal death contributes to many neurological disorders, and involves calcium influx and stress-activated protein kinases (SAPKs) such as p38 alpha. There is indirect evidence that the small Rho-family GTPases ...