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Umbilical cord blood DNA methylation in children who later develop type 1 diabetes

Grönroos Toni; Toppari Jorma; Konki Mikko; Halla-aho Viivi; Vähä-Mäkilä Mari; Kalim Ubaid U; Nurmio Mirja; Lähdesmäki Harri; Laajala Essi; Lahesmaa Riitta; Orešič Matej; Hyöty Heikki; Kallionpää Henna; Mykkänen Juha; Rasool Omid; Knip Mikael; Kattelus Roosa; Lietzen Niina; Lund Riikka J; Ilonen Jorma; Veijola Riitta; Ghimire Bishwa R; Elo Laura L; Laiho Asta

Aims/hypothesis: Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine whether perinatal DNA ...

Type 1 Diabetes in Children With Genetic Risk May Be Predicted Very Early With a Blood miRNA

Lahesmaa Riitta; Nurmio Mirja; Toppari Jorma; Mykkänen Juha; Knip Mikael; Elo Laura L; Kalim Ubaid Ullah; Laiho Asta; Rasool Omid; Kallionpää Henna; Ilonen Jorma; Härkönen Taina; Suomi Tomi; Hyöty Heikki; Vähä-Mäkilä Mari; Veijola Riitta

Early DNA methylation changes in children developing beta cell autoimmunity at a young age

Junttila Sini; Tillmann Vallo; Kattelus Roosa; Starskaia Inna; Suni Veronika; Laajala Essi; Lund Riikka; Elo Laura L. Lähdesmäki Harri; Laiho Asta; Grönroos Toni; Lahesmaa Riitta; Kalim Ubaid Ullah; Knip Mikael; Kallionpää Henna; Härkönen Taina

Aims/hypothesis Type 1 diabetes is a chronic autoimmune disease of complex aetiology, including a potential role for epigenetic regulation. Previous epigenomic studies focused mainly on clinically ...

Viral infection-related gene upregulation in monocytes in children with signs of β-cell autoimmunity

Knip Mikael; Veijola Riitta; Ezer Sini; Kere Juha; Katayama Shintaro; Yoshihara Masahito; Valta Milla; Pahkuri Sirpa; Toppari Jorma; Einarsdottir Elisabet; Ilonen Jorma; Lempainen Johanna

Objective: The pathogenesis of type 1 diabetes (T1D) is associated with genetic predisposition and immunological changes during presymptomatic disease. Differences in immune cell subset numbers and phenotypes between T1D ...

Associations between deduced first islet specific autoantibody with sex, age at diagnosis and genetic risk factors in young children with type 1 diabetes

Laine Antti-Pekka; Ilonen Jorma; Kiviniemi Minna; Härkonen Taina; Knip Mikael; Lempainen Johanna

Objectives We aimed to further characterize demography and genetic associations of type 1 diabetes "endotypes" defined by the first appearing islet specific autoantibodies. Research Design and Methods We analyzed 3277 ...