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Progression of type 1 diabetes from latency to symptomatic disease is predicted by distinct autoimmune trajectories
Development of islet autoimmunity precedes the onset of type 1 diabetes in children, however, the presence of autoantibodies does not necessarily lead to manifest disease and the onset of clinical symptoms is hard to ...
HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children
<p><b>Objective </b><br>Increased level of glycated hemoglobin (HbA1c) is associated with type 1 diabetes onset that in turn is preceded by one to several autoantibodies against the pancreatic islet beta cell autoantigens; ...
Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study
<p>The Environmental Determinants of Diabetes in the Young (TEDDY) study enrolled 8676 children, 3-4 months of age, born with HLA-susceptibility genotypes for islet autoimmunity (IA) and type 1 diabetes (T1D). Whole-genome ...
Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study
<p>Fungal infections are a major health problem that often begin in the gastrointestinal tract. Gut microbe interactions in early childhood are critical for proper immune responses, yet there is little known about the ...