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Association between microglial activation and serum kynurenine pathway metabolites in multiple sclerosis patients
<p>Background<br></p><p>Microglial activation associates with MS progression but it is unclear what drives their persistent pro-inflammatory state. Metabolites of the kynurenine pathway (KP), the main metabolism route of ...
Synaptic Loss in Multiple Sclerosis: A Systematic Review of Human Post-mortem Studies
<b>Background:</b> Gray matter pathology plays a central role in the progression of multiple sclerosis (MS). The occurrence of synaptic loss appears to be important but, to date, still poorly investigated aspect of MS ...
Atlas of type 2 dopamine receptors in the human brain: Age and sex dependent variability in a large PET cohort
<h3><br></h3><h3>Background</h3><p>The dopamine system contributes to a multitude of functions ranging from reward and motivation to learning and movement control, making it a key component in goal-directed behavior. Altered ...
Dimethyl fumarate decreases short-term but not long-term inflammation in a focal EAE model of neuroinflammation
<p>Background <br></p><p>Dimethyl fumarate (DMF) is an oral immunomodulatory drug used in the treatment of autoimmune diseases. Here, we sought to study whether the effect of DMF can be detected using positron emission ...
Cannabinoid Receptor Type 1 in Parkinson's Disease: A Positron Emission Tomography Study with [F-18]FMPEP-d(2)
<p><b>Background:</b> The endocannabinoid system is a widespread neuromodulatory system affecting several biological functions and processes. High densities of type 1 cannabinoid (CB1) receptors and endocannabinoids are ...