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Aineistot 1-10 / 32

68Ga-DOTA chelate, a novel imaging agent for assessment of myocardial perfusion and infarction detection in a rodent model

Heidi Liljenbäck; Vesa Oikonen; Juhani Knuuti; Max Kiugel; Sauli Uotila; Nobuyuki Kudomi; Ville Kytö; Semi Helin; Olli Metsälä; Anu Autio; Anne Roivainen; Antti Saraste

Background Magnetic resonance imaging (MRI) with Gadolinium 1,4,7,10-tetraazacyclododecane-N′,N″,N′′′,N″″-tetraacetic acid (Gd-DOTA) enables assessment of myocardial perfusion during first-pass of the contrast ...

First-in-Human Study of 68 Ga-DOTA-Siglec-9, PET Ligand Targeting Vascular Adhesion Protein 1

Saraste Antti; Jalkanen Sirpa; Moisio Olli Antero; Tolvanen Tuula; Taimen Kirsi; Koskivirta Ilpo; Nuutila Pirjo; Kohonen Ia; Knuuti Juhani; Lankinen Petteri; Viitanen Riikka; Suilamo Sami; Roivainen Anne; Mali Markku; Koivumäki Mikko; Li Xiang-Guo; Virtanen Helena; Autio Anu; Pirilä Laura; Oikonen Vesa; Santalahti Kristiina

Sialic acid-binding immunoglubulin-like lectin 9 (Siglec-9) is a ligand of vascular adhesion protein 1 (VAP-1). A gallium 68-labeled peptide of Siglec-9, 68Ga-DOTA-Siglec-9, holds promise as a novel PET tracer ...

Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol

Ibberson M; Saunavaara V; Gilchrist M; Papale M; Tobin K; Banks RE; Karihaloo A; de Zeeuw D; Heerspink HJL; Gooding KM; Shore AC; Andersson AMD; Pontrelli P; Kretzler M; Puppala S; Andress D; Bailey J; Grenier N; Metsarinne K; Lienczewski C; Gomez MF; Shelley D; Smith MW; Zetterqvist A; Sourbron S; Ball C; Maziarz M; Gesualdo L; Nuutila P; Gilmour PS; Mansfield M; Teh I; Sharma K; Koivuviita N; Hernandez AG

Background: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) ...

Mesenchymal Cell-Derived Juxtacrine Wnt1 Signaling Regulates Osteoblast Activity and Osteoclast Differentiation

Rummukainen P.; Nagano K.; Majidi R.A.; Mäkitie O.; Lehto J.; Wang F.; Roivainen A.; Nieminen-Pihala V.; Kiviranta R.; Tarkkonen K.; Zhang F.-P.; Puolakkainen T.; Baron R.

Human genetic evidence demonstrates that WNT1 mutations cause osteogenesis imperfecta (OI) and early‐onset osteoporosis, implicating WNT1 as a major regulator of bone metabolism. However, its main cellular source and ...

Evaluation of [68Ga]Ga-DOTA-TCTP-1 for the Detection of Metalloproteinase 2/9 Expression in Mouse Atherosclerotic Plaques

Knuuti J; Hellberg S; Kiugel M; Liljenbäck H; Saanijoki T; Saraste A; Roivainen A; Käkelä M; Li XG; Tuomela J

Background: The expression of matrix metalloproteinases 2/9 (MMP-2/9) has been implicated in arterial remodeling and inflammation in atherosclerosis. We evaluated a gallium-68 labeled peptide for the detection of MMP-2/9 ...

Morbid obesity and type 2 diabetes alter intestinal fatty acid uptake and blood flow

Karlsson Henry; Roivainen Anne; Koffert Jukka; Ståhle Mia; Iozzo Patricia; Salminen Paulina; Nuutila Pirjo

Aims: Bariatric surgery is the most effective treatment to tackle morbid obesity and type 2 diabetes, but the mechanisms of action are still unclear. The objective of this study was to investigate the effects of bariatric ...

Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice

Heidi Liljenbäck; Erik S.G. Stroes; Sanna Hellberg; Johanna M.U. Silvola; Margreet de Vries; Nina Savisto; Juhani Knuuti; Petteri Rinne; Jeffrey Kroon; Tommy Abrahamsson; Mia Ståhle; Knut Pettersson; Pekka Saukko; Anne Roivainen; Seppo Ylä-Herttuala; Alwin de Jong; Antti Saraste; Paul H. A. Quax; Anna Wickman

This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation ...

Physical Activity Associates with Muscle Insulin Sensitivity Postbariatric Surgery

Pham Tam; Salminen Paulina; Lehtimäki Terho; Heiskanen Marja A.; Nuutila Pirjo; Helmiö Mika; Hannukainen Jarna C.; Immonen Heidi; Savolainen Anna M.; Löyttyniemi Eliisa; Ovaska Jari; Karmi Anna; Mari Andrea; Saunavaara Virva; Soinio Minna

PurposeBariatric surgery is considered as an effective therapeutic strategy for weight loss in severe obesity. Remission of type 2 diabetes is often achieved following the surgery. We investigated whether increase in ...

Assessment of myocardial viability with [15O]water PET: A validation study in experimental myocardial infarction

Tuula Tolvanen; Mikko Pietilä; Mark Lubberink; Tuomas Kiviniemi; Timo Savunen; Juhani Knuuti; Mika Teräs; Seppo Ylä-Herttuala; Antti Saraste; Jarmo Teuho; Miikka Tarkia; Antti Kuivanen; Maria Grönman; Virva Saunavaara; Paavo Halonen; Anne Roivainen; Christoffer Stark; Tommi Vähäsilta

Background: Assessment of myocardial viability is often needed in patients with chest pain and reduced ejection fraction. We evaluated the performance of reduced resting MBF, perfusable tissue fraction (PTF), and ...

Systemic cross-talk between brain, gut, and peripheral tissues in glucose homeostasis: effects of exercise training (CROSSYS). Exercise training intervention in monozygotic twins discordant for body weight

Löyttyniemi Eliisa; Helmiö Mika; Lautamäki Riikka; Lahti Leo; Saunavaara Jani; Lietzen Martin S; Pietiläinen Kirsi H; Honkala Sanna M; Collado Maria C; Hentilä Jaakko; Kaprio Jaakko; Malm Tarja; Nummenmaa Lauri; Saunavaara Virva; Koskensalo Kalle; Ojala Ronja; Hannukainen Jarna C; Rinne Juha O; Heiskanen Marja A

Background: Obesity and physical inactivity are major global public health concerns, both of which increase the risk of insulin resistance and type 2 diabetes. Regulation of glucose homeostasis involves cross-talk between ...