Hae

Aineistot 1-10 / 29

68Ga-DOTA chelate, a novel imaging agent for assessment of myocardial perfusion and infarction detection in a rodent model

Heidi Liljenbäck; Vesa Oikonen; Juhani Knuuti; Max Kiugel; Sauli Uotila; Nobuyuki Kudomi; Ville Kytö; Semi Helin; Olli Metsälä; Anu Autio; Anne Roivainen; Antti Saraste

Background Magnetic resonance imaging (MRI) with Gadolinium 1,4,7,10-tetraazacyclododecane-N′,N″,N′′′,N″″-tetraacetic acid (Gd-DOTA) enables assessment of myocardial perfusion during first-pass of the contrast ...

First-in-Human Study of 68 Ga-DOTA-Siglec-9, PET Ligand Targeting Vascular Adhesion Protein 1

Saraste Antti; Jalkanen Sirpa; Moisio Olli Antero; Tolvanen Tuula; Taimen Kirsi; Koskivirta Ilpo; Nuutila Pirjo; Kohonen Ia; Knuuti Juhani; Lankinen Petteri; Viitanen Riikka; Suilamo Sami; Roivainen Anne; Mali Markku; Koivumäki Mikko; Li Xiang-Guo; Virtanen Helena; Autio Anu; Pirilä Laura; Oikonen Vesa; Santalahti Kristiina

Sialic acid-binding immunoglubulin-like lectin 9 (Siglec-9) is a ligand of vascular adhesion protein 1 (VAP-1). A gallium 68-labeled peptide of Siglec-9, 68Ga-DOTA-Siglec-9, holds promise as a novel PET tracer ...

Prognostic imaging biomarkers for diabetic kidney disease (iBEAt): study protocol

Ibberson M; Saunavaara V; Gilchrist M; Papale M; Tobin K; Banks RE; Karihaloo A; de Zeeuw D; Heerspink HJL; Gooding KM; Shore AC; Andersson AMD; Pontrelli P; Kretzler M; Puppala S; Andress D; Bailey J; Grenier N; Metsarinne K; Lienczewski C; Gomez MF; Shelley D; Smith MW; Zetterqvist A; Sourbron S; Ball C; Maziarz M; Gesualdo L; Nuutila P; Gilmour PS; Mansfield M; Teh I; Sharma K; Koivuviita N; Hernandez AG

Background: Diabetic kidney disease (DKD) remains one of the leading causes of premature death in diabetes. DKD is classified on albuminuria and reduced kidney function (estimated glomerular filtration rate (eGFR)) ...

Rare protein-altering variants in ANGPTL7 lower intraocular pressure and protect against glaucoma

Palotie Aarno; Havulinna Aki S; Venkataraman Guhan; Tanigawa Yosuke; Perola Markus; Lemmelä Susanna; Graham Robert R; Kiiskinen Tuomo; Wainberg Michael; Turunen Joni A; Karjalainen Juha; Daly Mark J; Rivas Manuel A; FinnGen

Protein-altering variants that are protective against human disease provide in vivo validation of therapeutic targets. Here we use genotyping data from UK Biobank (n = 337,151 unrelated White British individuals) and FinnGen ...

Evaluation of [68Ga]Ga-DOTA-TCTP-1 for the Detection of Metalloproteinase 2/9 Expression in Mouse Atherosclerotic Plaques

Knuuti J; Hellberg S; Kiugel M; Liljenbäck H; Saanijoki T; Saraste A; Roivainen A; Käkelä M; Li XG; Tuomela J

Background: The expression of matrix metalloproteinases 2/9 (MMP-2/9) has been implicated in arterial remodeling and inflammation in atherosclerosis. We evaluated a gallium-68 labeled peptide for the detection of MMP-2/9 ...

Morbid obesity and type 2 diabetes alter intestinal fatty acid uptake and blood flow

Karlsson Henry; Roivainen Anne; Koffert Jukka; Ståhle Mia; Iozzo Patricia; Salminen Paulina; Nuutila Pirjo

Aims: Bariatric surgery is the most effective treatment to tackle morbid obesity and type 2 diabetes, but the mechanisms of action are still unclear. The objective of this study was to investigate the effects of bariatric ...

Genetic architecture of human plasma lipidome and its link to cardiovascular disease

Palta P; Whelan C; Laukkanen J; Hannula-Jouppi K; Kaarniranta K; Runz H; Challis B; Ripatti S; Hu XL; Call K; Hiltunen M; Simons K; Peterson A; Pitkanen K; Pikkarainen S; Zhou W; Soderlund S; Savinainen K; Soini S; Isomaki P; Carpen O; Smaoui N; Kujala U; Bowers N; Voutilainen M; Lehtonen A; Eaton S; Kaprio J; Ollila T; Kangasniemi E; Tuomi T; Landenpera S; Mannermaa A; Makela T; Teng E; Muslin A; Chang D; Huhtakangas J; Service SK; Mantere T; Auro K; Klinger K; Laukkanen M; Fox C; Kristiansson K; Waring J; Kononen J; Kiviniemi M; Kilpelainen E; Chen X; Laakkonen E; Rivas M; Elenius K; Harju T; Soininen H; Metsarinne K; Plenge R; Palotie A; Pelkonen M; Kurki M; Donner K; Yang R; Podgornaia A; Tuovila O; Schutzman J; Awaisa G; Sistonen T; Loukola A; Kuopio T; Perola M; Davis JW; Karlsson A; Xu FL; Joensuu H; Palin K; Laakso M; Biswas S; Parr K; Close D; Eicher J; Turunen J; McDonough S; Siirtola H; Kulkarni D; Surma MA; Hiekkalinna T; Pirinen M; Gordillo JE; Klose C; Paloneva J; Koulu L; Chen CY; Karihtala P; Popovic R; Kiiskinen TTJ; Waterworth D; Laivuori H; Mattsson H; Koskinen M; Kalpala K; Diogo D; Petrovski S; Wang XL; Kalaoja M; Usiskin K; Marshal C; Oh D; Hendolin M; Strauss E; Georgantas B; McCarthy M; Wu Y; Lahteenmaki S; Kaarteenaho R; Schleutker J; Uusitalo-Jarvinen H; Riley-Gillis B; Pulkki K; Liu J; Salomaa V; Ganna A; Kaipiainen-Seppanen O; Freimer NB; Taskinen MR; Chhibber A; Tabuenca JG; Lemmela S; Wong R; Kajanne R; McCarthy L; Hoffman J; Hinttala R; Gerl MJ; Shcherban A; Aaltonen L; Chu A; Jauhiainen M; Daly MJ; Virolainen P; Mannikko L; Ritari J; Koskela JT; Bhangale T; Pakkanen R; Uusitalo H; Kalviainen R; Hyvarinen K; John S; Kosma VM; Sipila T; Pylkas K; Maranville J; Blomster T; Ziemann A; Wahlfors T; Auge F; Mehta V; Pitkaranta A; Bing N; Harju J; Lehtonen H; Michon J; Meretoja T; Chen H; Niiranen T; Betts J; Kaunisto M; Llorens V; Ehm M; Laitinen T; Julkunen V; Tabassum R; Peltola J; Nunez-Fontarnau J; Lertratanakul A; Karjalainen M; Seitsonen S; Palomaki A; Auranen A; Holzinger E; Lyhs U; Heikkinen S; Gormley P; Tienari P; Peltonen S; Pihlajamaki J; Auvinen P; Kauppi P; Hunkapiller J; Gossel M; Matikainen N; Wang C; Luodonpaa M; Rinne J; Partanen J; Hedman A; Hassan S; Jimenez MG; Eklund K; Huilaja L; Kerchner G; Aaltonen V; Pirila L; Dada A; Kahonen M; Heap G; Harvima I; Crohns M; Hochfeld M; Lehisto A; Tasanen K; Loboda A; Junttila J; Ripatti P; Jalanko A; Pulford D; Hautala N; Kallio L; Juonala M; Parkkinen J; Ramo JT; Esmaeeli S; Matakidou A; Sipila TP; Linden K; Salmi T; Parolo PD; Greenberg S; Brein G; Miller M; Laiho P; Kettunen J; Malarstig A; Karjalainen J; Jacob H; Vainio S; Bronson P; Chatelain C; Laaksonen R; Rahimov F; Arvas M; Lu T; Quarless D; Xu E; Stitziel NO; Jussila A; Remes A; Sinisalo J; Havulinna AS; Kaiharju E; Kilpi T; Jarvensivu E; Mars N; Kauppila S; Farkkila M; Kankaanranta H; Ghosh S

Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species ...

Genomic prediction of alcohol-related morbidity and mortality

Madden PAF; Mars NJ; Makela P; Koskela J; Salomaa V; Kiiskinen T; Rose RJ; Palotie A; Kaprio J; Ramo JT; Havulinna AS; Ripatti P; Ripatti S; Palviainen T; Ruotsalainen S

While polygenic risk scores (PRS) have been shown to predict many diseases and risk factors, the potential of genomic prediction in harm caused by alcohol use has not yet been extensively studied. Here, we built a novel ...

Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular 18F-FDG Uptake in Atherosclerotic Mice

Heidi Liljenbäck; Erik S.G. Stroes; Sanna Hellberg; Johanna M.U. Silvola; Margreet de Vries; Nina Savisto; Juhani Knuuti; Petteri Rinne; Jeffrey Kroon; Tommy Abrahamsson; Mia Ståhle; Knut Pettersson; Pekka Saukko; Anne Roivainen; Seppo Ylä-Herttuala; Alwin de Jong; Antti Saraste; Paul H. A. Quax; Anna Wickman

This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation ...

Assessment of myocardial viability with [15O]water PET: A validation study in experimental myocardial infarction

Tuula Tolvanen; Mikko Pietilä; Mark Lubberink; Tuomas Kiviniemi; Timo Savunen; Juhani Knuuti; Mika Teräs; Seppo Ylä-Herttuala; Antti Saraste; Jarmo Teuho; Miikka Tarkia; Antti Kuivanen; Maria Grönman; Virva Saunavaara; Paavo Halonen; Anne Roivainen; Christoffer Stark; Tommi Vähäsilta

Background: Assessment of myocardial viability is often needed in patients with chest pain and reduced ejection fraction. We evaluated the performance of reduced resting MBF, perfusable tissue fraction (PTF), and ...