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An Infancy-Onset 20-Year Dietary Counselling Intervention and Gut Microbiota Composition in Adulthood

Jula Antti; Rönnemaa Tapani; Keskitalo Anniina; Kartiosuo Noora; Rovio Suvi P; Pahkala Katja; Lahti Leo; Huovinen Pentti; Pietilä Sami; Niinikoski Harri; Aatsinki Anna; Raitakari Olli; Elo Laura L; Lagström Hanna; Viikari Jorma; Munukka Eveliina; Saleem Wisam

An Infancy-Onset 20-Year Dietary Counselling Intervention and Gut Microbiota Composition in Adulthood

Jula Antti
Rönnemaa Tapani
Keskitalo Anniina
Kartiosuo Noora
Rovio Suvi P
Pahkala Katja
Lahti Leo
Huovinen Pentti
Pietilä Sami
Niinikoski Harri
Aatsinki Anna
Raitakari Olli
Elo Laura L
Lagström Hanna
Viikari Jorma
Munukka Eveliina
Saleem Wisam
Katso/Avaa
nutrients-14-02667-v2.pdf (8.808Mb)
Lataukset: 

MDPI
doi:10.3390/nu14132667
URI
https://www.mdpi.com/2072-6643/14/13/2667
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022091258410
Tiivistelmä
The randomized controlled Special Turku Coronary Risk Factor Intervention Project (STRIP) has completed a 20-year infancy-onset dietary counselling intervention to reduce exposure to atherosclerotic cardiovascular disease risk factors via promotion of a heart-healthy diet. The counselling on, e.g., low intake of saturated fat and cholesterol and promotion of fruit, vegetable, and whole-grain consumption has affected the dietary characteristics of the intervention participants. By leveraging this unique cohort, we further investigated whether this long-term dietary intervention affected the gut microbiota bacterial profile six years after the intervention ceased. Our sub-study comprised 357 individuals aged 26 years (intervention n = 174, control n = 183), whose gut microbiota were profiled using 16S rRNA amplicon sequencing. We observed no differences in microbiota profiles between the intervention and control groups. However, out of the 77 detected microbial genera, the Veillonella genus was more abundant in the intervention group compared to the controls (log(2) fold-change 1.58, p < 0.001) after adjusting for multiple comparison. In addition, an association between the study group and overall gut microbiota profile was found only in males. The subtle differences in gut microbiota abundances observed in this unique intervention setting suggest that long-term dietary counselling reflecting dietary guidelines may be associated with alterations in gut microbiota.
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