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Distinct Diet-Microbiota-Metabolism Interactions in Overweight and Obese Pregnant Women: a Metagenomics Approach

Munukka Eveliina; Nielsen Henrik Bjørn; Houttu Noora; Sørensen Nikolaj; Mokkala Kati.; Koivuniemi Ella; Laitinen Kirsi; Lotankar Mrunalini; Lahti Leo

Distinct Diet-Microbiota-Metabolism Interactions in Overweight and Obese Pregnant Women: a Metagenomics Approach

Munukka Eveliina
Nielsen Henrik Bjørn
Houttu Noora
Sørensen Nikolaj
Mokkala Kati.
Koivuniemi Ella
Laitinen Kirsi
Lotankar Mrunalini
Lahti Leo
Katso/Avaa
spectrum.00893-21.pdf (354.2Kb)
Lataukset: 

American Society for Microbiology
doi:10.1128/spectrum.00893-21
URI
https://journals.asm.org/doi/10.1128/spectrum.00893-21
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022081153624
Tiivistelmä

Diet and gut microbiota are known to modulate metabolic health. Our aim was to apply a metagenomics approach to investigate whether the diet-gut microbiota-metabolism and inflammation relationships differ in pregnant overweight and obese women. This cross-sectional study was conducted in overweight (n = 234) and obese (n = 152) women during early pregnancy. Dietary quality was measured by a validated index of diet quality (IDQ). Gut microbiota taxonomic composition and species diversity were assessed by metagenomic profiling (Illumina HiSeq platform). Markers for glucose metabolism (glucose, insulin) and low-grade inflammation (high sensitivity C-reactive protein [hsCRP], glycoprotein acetylation [GlycA]) were analyzed from blood samples. Higher IDQ scores were positively associated with a higher gut microbiota species diversity (r = 0.273, P = 0.007) in obese women, but not in overweight women. Community composition (beta diversity) was associated with the GlycA level in the overweight women (P = 0.04) but not in the obese. Further analysis at the species level revealed a positive association between the abundance of species Alistipes finegoldii and the GlycA level in overweight women (logfold change = 4.74, P = 0.04). This study has been registered at ClinicalTrials.gov under registration no. NCT01922791 (https://clinicaltrials.gov/ct2/show/NCT01922791).

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