Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration
O'Connell J; Li C; Rankinen T; Morrison AC; Wagenknecht LE; Redline S; Marten J; Kühnel B; Psaty BM; Aschard H; Alver M; Zhu X; Rice TK; Lim E; Shu XO; Winkler TW; Wang H; Lakka TA; Evans MK; Manning A; Aslibekyan S; Snieder H; Gieger C; Arnett DK; Sidney SS; Rensen PCN; Nolte IM; Liu J; Amin N; Lehtimäki T; Rice K; Roenneberg T; Peyser P; Marques-Vidal P; Richard M; Boerwinkle E; He M; van der Spek A; Haba-Rubio J; Palmer ND; Peters A; Cupples LA; Loos RJF; Gauderman WJ; Sung YJ; Guo X; Bentley AR; Taylor KD; Milaneschi Y; Bouchard C; Noordam R; Kritchevsky SB; Gao C; Rauramaa R; Bielak L; Kardia S; Kraja A; Adolfo C; Sims M; Munroe PB; Rich SS; Province M; Waldenberger M; Laville V; de Vries PS; Liu Y; Lee J; Gharib SA; Weiss S; Chen H; Schwander K; Strauch K; Kho M; Wu T; Elliott P; van Dijk KW; Homuth G; Lohman KK; Graff ME; Martin LW; Lyytikäinen LP; Schreiner PJ; Becker DM; Kelly TN; Penninx BWJH; Gottlieb DJ; Liu CT; Horimoto AR; Ilkov M; Gudnason V; Raitakari OT; Heinzer R; Zheng W; Kooperberg C; Komulainen P; Yu C; Krieger JE; Evangelou E; Fox EF; Ballantyne C; van Heemst D; van Duijn CM; Xiang YB; Metspalu A; Feitosa M; Mook-Kanamori DO; Hixson JE; Zonderman AB; Wallance RB; Eiriksdottir G; Vojinovic D; Cade BE; Rotimi C; Sofer T; Rotter JI; Franceschini N; Ikram MA; Nalls MA; Bos MM; Grabe HJ; Tajuddin SM; Biermasz NR; Heikkinen S; Swertz MA; Shikany J; Mägi R; Kilpeläinen TO; Wen W; North KE; Reiner AP; Vollenweider P; Fornage M; Wang Z; Völzke H; Luik AI; Dimou N; Bartz TM; Brown MR; Uitterlinden AG; Sitlani CM; Pereira AC; Harris TB; Esko T; Meitinger T; Rao DC; Musani SK; Yanek LR; de Las Fuentes L
https://urn.fi/URN:NBN:fi-fe2021042821137
Tiivistelmä
Both short and long sleep are associated with an adverse lipid profile,
likely through different biological pathways. To elucidate the biology
of sleep-associated adverse lipid profile, we conduct multi-ancestry
genome-wide sleep-SNP interaction analyses on three lipid traits (HDL-c,
LDL-c and triglycerides). In the total study sample
(discovery + replication) of 126,926 individuals from 5 different
ancestry groups, when considering either long or short total sleep time
interactions in joint analyses, we identify 49 previously unreported
lipid loci, and 10 additional previously unreported lipid loci in a
restricted sample of European-ancestry cohorts. In addition, we identify
new gene-sleep interactions for known lipid loci such as LPL and PCSK9.
The previously unreported lipid loci have a modest explained variance
in lipid levels: most notable, gene-short-sleep interactions explain
4.25% of the variance in triglyceride level. Collectively, these
findings contribute to our understanding of the biological mechanisms
involved in sleep-associated adverse lipid profiles.
Kokoelmat
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