p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
Kageyama Shun; Eskelinen Eeva-Liisa; Komatsu Masaaki
p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control
Kageyama Shun
Eskelinen Eeva-Liisa
Komatsu Masaaki
TAYLOR & FRANCIS INC
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042821164
https://urn.fi/URN:NBN:fi-fe2021042821164
Tiivistelmä
Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear factor erythroid 2-related factor 2 (NRF2) activation. Further, p62-mediated NRF2 activation is not cytotoxic, but combination of NRF2 activation with impaired bulk and selective autophagy causes liver injury.
Kokoelmat
- Rinnakkaistallenteet [19207]