Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry
Burkert M. Pieske; Christian Ukena; Rafal Dworakowski; Abhiram Prasad; Guido ichels; Claudius Jacobshagen; Roman Pfister; Olivier Lairez; Michel Noutsias; Grzegorz Opolski; Hugo A. Katus; John D. Horowitz; Ibrahim Akin; Gerd Hasenfuß; Christof Burgdorf; and Christian Templin; L. Christian Napp; Maike Knorr; Wolfgang Rottbauer; Thomas Münzel; Mikhail Gilyarov; Konrad A. zawan; Leonarda Galiuto; Fabrizio D'Ascenzo; Beatrice Bacchi; Jozef Micek; Wolfgang Koenig; Martin Borggrefe; Lawrence Rajan; Filippo Crea; Clément Delmas; Carlo Di Mario; Frank Ruschitzka; Eduardo Bossone; Tuija Vasankari; Jennifer Franke; Antonio H. Frangieh; Christoph Kaiser; Thomas A. Fischer; K. E. Juhani Airaksinen; Davide Di Vece; Ken Kato; Martin Kozel; Stefan Osswald; Ibrahim El‐Battrawy; Petr Widimský; Jeroen J. Bax; Michael Böhm; Annahita Sarcon; Stephan B. Felix; Burkhardt Seifert; Alexandra Shilova; Wolfgang Dichtl; Petr Tousek; Ruediger C. Braun‐Dullaeus; Rodolfo Citro; Alessandro Cuneo; Adrian Banning; Thomas F. Lüscher; Sebastiano Gili; Katharina J. Ding; Stjepan Jurisic; Holger Thiele; Richard Kobza; Susanne Heiner; Mahir Karakas; Florim Cuculi; Milosz Jaguszewski; Philip MacCarthy; Ekaterina Gilyarova; Jerold Shinbane; Johann Bauersachs; David E. Winchester; Carsten Tschöpe; Jelena R. Ghadri; Victoria L. Cammann; Heribert Schunkert
https://urn.fi/URN:NBN:fi-fe2021042821223
Tiivistelmä
Background
Clinical characteristics and outcomes of takotsubo syndrome (TTS)
patients with malignancy have not been fully elucidated. This study
sought to explore differences in clinical characteristics and to
investigate short‐ and long‐term outcomes in TTS patients with or without malignancy.
Methods and Results
TTS patients were enrolled from the International Takotsubo Registry. The TTS
cohort was divided into patients with and without malignancy to
investigate differences in clinical characteristics and to assess short‐
and long‐term mortality. A subanalysis was performed comparing
long‐term mortality between a subset of TTS
patients with or without malignancy and acute coronary syndrome (ACS)
patients with or without malignancy. Malignancy was observed in 16.6% of
1604 TTS
patients. Patients with malignancy were older and more likely to have
physical triggers, but less likely to have emotional triggers compared
with those without malignancy. Long‐term mortality was higher in
patients with malignancy (P<0.001), while short‐term outcome was comparable (P=0.17). In a subanalysis, long‐term mortality was comparable between TTS patients with malignancies and ACS patients with malignancies (P=0.13). Malignancy emerged as an independent predictor of long‐term mortality.
Conclusions
A substantial number of TTS patients show an association with malignancy. History of malignancy might increase the risk for TTS, and therefore, appropriate screening for malignancy should be considered in these patients.
Kokoelmat
- Rinnakkaistallenteet [19207]