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Herpesvirus infections in adenoids in patients with chronic adenotonsillar disease

Waris Matti; Puhakka Tuomo; Mikola Emilia; Jartti Tuomas; Ivaska Lotta E; Silvoniemi Antti; Vuorinen Tytti

Herpesvirus infections in adenoids in patients with chronic adenotonsillar disease

Waris Matti
Puhakka Tuomo
Mikola Emilia
Jartti Tuomas
Ivaska Lotta E
Silvoniemi Antti
Vuorinen Tytti
Katso/Avaa
Journal of Medical Virology - 2022 - Ivaska - Herpesvirus infections in adenoids in patients with chronic adenotonsillar.pdf (1.396Mb)
Lataukset: 

WILEY
doi:10.1002/jmv.27818
URI
https://onlinelibrary.wiley.com/doi/epdf/10.1002/jmv.27818
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022081153671
Tiivistelmä
Adenoids and tonsils have gained interest as a new in vivo model to study local immune functions and virus reservoirs. Especially herpesviruses are interesting because their prevalence and persistence in local lymphoid tissue are incompletely known. Our aim was to study herpesvirus and common respiratory virus infections in nonacutely ill adenotonsillar surgery patients. Adenoid and/or palatine tonsil tissue and nasopharyngeal aspirate (NPA) samples were collected from elective adenoidectomy (n = 45) and adenotonsillectomy (n = 44) patients (median age: 5, range: 1-20). Real-time polymerase chain reaction was used to detect 22 distinct viruses from collected samples. The overall prevalence of herpesviruses was 89% and respiratory viruses 94%. Human herpesviruses 6 (HHV6), 7 (HHV7), and Epstein-Barr virus (EBV) were found, respectively, in adenoids (33%, 26%, 25%), tonsils (45%, 52%, 23%), and NPA (46%, 38%, 25%). Copy numbers of the HHV6 and HHV7 genome were significantly higher in tonsils than in adenoids. Patients with intra-adenoid HHV6 were younger than those without. Detection rates of EBV and HHV7 showed agreement between corresponding sample types. This study shows that adenoid and tonsil tissues commonly harbor human herpes- and respiratory viruses, and it shows the differences in virus findings between sample types.
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