Hyppää sisältöön
    • Suomeksi
    • In English
  • Suomeksi
  • In English
  • Kirjaudu
Näytä aineisto 
  •   Etusivu
  • 3. UTUCris-artikkelit
  • Rinnakkaistallenteet
  • Näytä aineisto
  •   Etusivu
  • 3. UTUCris-artikkelit
  • Rinnakkaistallenteet
  • Näytä aineisto
JavaScript is disabled for your browser. Some features of this site may not work without it.

Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases

Z. Feng; K. Govindasami; C. Sipeky; A. Leonardson; H. Gronberg; L. M. FitzGerald; S. Kolb; J. Schleutker; R. Eeles; S. Zhao; T. L. Tammela; J. Hugosson; M. J. Stampfer; E. A. Ostrander; F. Wiklund; Z. Kote-Jarai; G. G. Giles; J. L. Stanford; P. Stattin; D. M. Karyadi; J. L. Wright; D. W. Lin; M. S. Geybels; M. C. Southey; K. L. Penney

Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases

Z. Feng
K. Govindasami
C. Sipeky
A. Leonardson
H. Gronberg
L. M. FitzGerald
S. Kolb
J. Schleutker
R. Eeles
S. Zhao
T. L. Tammela
J. Hugosson
M. J. Stampfer
E. A. Ostrander
F. Wiklund
Z. Kote-Jarai
G. G. Giles
J. L. Stanford
P. Stattin
D. M. Karyadi
J. L. Wright
D. W. Lin
M. S. Geybels
M. C. Southey
K. L. Penney
Katso/Avaa
Publisher's version (619.6Kb)
Lataukset: 

Nature Publishing Group
doi:10.1038/s41391-017-0029-2
Näytä kaikki kuvailutiedot
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042718870
Tiivistelmä

Background

Prostate
cancer (PCa) is a leading cause of mortality and genetic factors can
influence tumour aggressiveness. Several germline variants have been
associated with PCa-specific mortality (PCSM), but further replication
evidence is needed.

Methods

Twenty-two
previously identified PCSM-associated genetic variants were genotyped
in seven PCa cohorts (12,082 patients; 1544 PCa deaths). For each
cohort, Cox proportional hazards models were used to calculate hazard
ratios and 95% confidence intervals for risk of PCSM associated with
each variant. Data were then combined using a meta-analysis approach.

Results

Fifteen
SNPs were associated with PCSM in at least one of the seven cohorts. In
the meta-analysis, after adjustment for clinicopathological factors,
variants in the MGMT (rs2308327; HR 0.90; p-value = 3.5 × 10−2) and IL4 (rs2070874; HR 1.22; p-value = 1.1 × 10−3)
genes were confirmed to be associated with risk of PCSM. In analyses
limited to men diagnosed with local or regional stage disease, a variant
in AKT1, rs2494750, was also confirmed to be associated with PCSM risk (HR 0.81; p-value = 3.6 × 10−2).

Conclusions

This
meta-analysis confirms the association of three genetic variants with
risk of PCSM, providing further evidence that genetic background plays a
role in PCa-specific survival. While these variants alone are not
sufficient as prognostic biomarkers, these results may provide insights
into the biological pathways modulating tumour aggressiveness.

Kokoelmat
  • Rinnakkaistallenteet [19207]

Turun yliopiston kirjasto | Turun yliopisto
julkaisut@utu.fi | Tietosuoja | Saavutettavuusseloste
 

 

Tämä kokoelma

JulkaisuajatTekijätNimekkeetAsiasanatTiedekuntaLaitosOppiaineYhteisöt ja kokoelmat

Omat tiedot

Kirjaudu sisäänRekisteröidy

Turun yliopiston kirjasto | Turun yliopisto
julkaisut@utu.fi | Tietosuoja | Saavutettavuusseloste