The feasibility of [F-18]EF5-PET/CT to image hypoxia in ovarian tumors: a clinical study
Marko Seppänen; Sarita Forsback; Maren Laasik; Sakari Hietanen; Johanna Hynninen; Tommi Noponen
The feasibility of [F-18]EF5-PET/CT to image hypoxia in ovarian tumors: a clinical study
Marko Seppänen
Sarita Forsback
Maren Laasik
Sakari Hietanen
Johanna Hynninen
Tommi Noponen
SPRINGER
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042821410
https://urn.fi/URN:NBN:fi-fe2021042821410
Tiivistelmä
Rationale Evaluation of the feasibility of [F-18]EF5-PET/CT scan in identifying hypoxic lesions in ovarian tumors in prospective clinical setting.
Methods Fifteen patients with a suspected malignant ovarian tumor were scanned with [F-18]EF5 and [F-18]FDG-PET/CT preoperatively. The distribution of [F-18]EF5-uptake, total intraabdominal metabolic tumor volume (TMTV), and hypoxic subvolume (HSV) were assessed.
Results [F-18]EF5-PET/CT suggested hypoxia in 47% (7/15) patients. The median HSV was 87 cm(3)(31% of TMTV). The [F-18]EF5-uptake was detected in primary tumors and in four patients also in intra-abdominal metastases. The [F-18]EF5-uptake in cancer tissue was low compared to physiological excretory pathways, complicating the interpretation of PET/CT images.
Conclusions [F-18]EF5-PET/CT is not feasible in ovarian cancer imaging in clinical setting due to physiological intra-abdominal [F-18]EF5-accumulation. However, it may be useful when used complementarily to FDG-PET/CT.
Kokoelmat
- Rinnakkaistallenteet [19207]