Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults
Vestergaard H; Heid IM; Liu CT; Gordon-Larsen P; Vandenput L; den Hoed M; Grallert H; Weir DR; Haller T; Lorentzon M; Blangero J; Ridker PM; Lohman K; Männikkö R; Hansen T; Peters A; Lemarchand L; Sarti C; Olden M; Johnson AD; Huang T; Vohl MC; Mohlke KL; Völker U; Holmens OL; Bandinelli S; Loos RJF; Buyske S; Griffin PJ; Hartman CA; Vollenweider P; Sanna S; Luben R; Qi L; Lehne B; Waeber G; Perola M; De Moor MHM; Lindgren CM; Campbell H; van Grootheest G; Snieder H; Jhun MA; Harris TB; Vitart V; Salomaa V; Wareham NJ; Hofman A; Workalemahu T; Wilson JF; Walker M; Nolte IM; Aadahl M; Bielak LF; Cadby G; Bergmann S; Dueker N; Langenberg C; Hollensted M; Wright AF; Mangino M; Boomsma DI; Justice AE; Monda KL; Rauramaa R; Montgomery GW; Collins FS; Xue LT; Kolcic I; Fornage M; Mahajan A; Pedersen O; Kähönen M; Huppertz C; Glaser S; Klein RJ; Thorand B; Grammer TB; Bouchard C; Corre T; Marques-Vidal PM; Jansson JO; Milaneschi Y; Hindorff L; Amin N; Scott RA; Pasko D; Kooperberg C; Bragg-Gresham JL; Sidney S; Kivimäki M; Ngwa JS; Chu AY; Gieger C; Barroso I; Magl R; Tammelin T; Borja JB; Eriksson J; Dorr M; Smith AV; Kooner JS; Busonero F; Faul JD; Bonnefond A; Luan J; Lakka TA; Kinnunen L; Boerwinkle E; Rose LM; Teumer A; Frayling TM; Juonala M; Abecasis GR; Lim E; Brage S; Demirkan A; North KE; McCarthy MI; Swift AJ; Oldehinkel AJ; Kristiansson K; Hernandez D; Stringham HM; Hottenga JJ; Eicher JD; Adair LS; Sternfeld B; Zhao JH; Bien S; Metspalu A; Ahmad S; Ohlsson C; Qi QB; Zubair N; Quaye L; Koistinen HA; James AL; Wild S; Snitker S; Holzapfel C; Justesen JM; Faerch K; Rankinen T; Scott WR; Whitfield JB; Hutri-Kähönen N; Winkler TW; Tan ST; Fu M; Strauch K; Kleber ME; Gong J; Huth C; Chasman DI; Cornelis M; Martin NG; van Vliet-Ostaptchouk JV; Peters U; Cheng YC; Kilpeläinen TO; Lim U; Tönjes A; Hui J; Kuusisto J; Huffman JE; Graff M; Lehtimaki T; Raitakari OT; Paternoster L; Porteous DJ; Hveem K; Young KL; Ebeling T; Rasmussen-Torvik LJ; Perez J; Hirschhorn JN; Heard-Costa NL; Järvelin MR; Harder MN; Marz W; Männistö S; Chambers JC; Smith JA; Marten J; Jackson AU; Fox CS; Hadley D; Komulainen P; Grarup N; Launer LJ; Chines PS; Linneberg A; Shuldiner AR; Sarzynski MA; Hallmans G; Bertoni AG; Silbernagel G; Cupples LA; Thuillier D; Ahluwalia TS; Strachan DP; Smith BH; Rivadeneira F; Mulas A; Sørensen TIA; Franks PW; Willemsen G; Van der Most PJ; Kvaløy K; Borecki IB; Liu YM; Huang J; Johansson A; Auvinen J; Kutalik Z; Völzke H; O'Connell JR; Savonen K; Penninx BWJH; Hayward C; de Geus EJC; Tuomilehto J; Ong KK; Uitterlinden AG; Peyser PA; Feitosa MF; Smith GD; Hastie ND; Rudan I; Kumari M; Rivera NV; Musk AW; Rawal R; van Duijn CM; Yengo L; Gyllensten U; Gudnason V; Boehnke M; Hocking LJ; Hassinen M; Zillikens MC; Wu Y; Nauck M; Renström F; Kardia SLR; Padmanabhan S; Havulinna AS; Stančáková A; Narisu N; Esko T; Balkau B; Beilby J; Palmer LJ; Eiriksdottir G; Peyrot WJ; Bonnycastle LL; Kuh D; Lyytikäinen LP; Zhao W; Marre M; Wong A; Pérusse L; Haiman CA; Puolijoki H; Nettleton JA; Müller-Nurasyid M; Polasek O; Navarro P; Laakso M; Hayes JE; Prokopenko I; Cucca F; Zhang WH; Bellis C; Barata L; Froguel P; Bergman RN; Tanaka T; Harald K; Delgado GE
Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults
Vestergaard H
Heid IM
Liu CT
Gordon-Larsen P
Vandenput L
den Hoed M
Grallert H
Weir DR
Haller T
Lorentzon M
Blangero J
Ridker PM
Lohman K
Männikkö R
Hansen T
Peters A
Lemarchand L
Sarti C
Olden M
Johnson AD
Huang T
Vohl MC
Mohlke KL
Völker U
Holmens OL
Bandinelli S
Loos RJF
Buyske S
Griffin PJ
Hartman CA
Vollenweider P
Sanna S
Luben R
Qi L
Lehne B
Waeber G
Perola M
De Moor MHM
Lindgren CM
Campbell H
van Grootheest G
Snieder H
Jhun MA
Harris TB
Vitart V
Salomaa V
Wareham NJ
Hofman A
Workalemahu T
Wilson JF
Walker M
Nolte IM
Aadahl M
Bielak LF
Cadby G
Bergmann S
Dueker N
Langenberg C
Hollensted M
Wright AF
Mangino M
Boomsma DI
Justice AE
Monda KL
Rauramaa R
Montgomery GW
Collins FS
Xue LT
Kolcic I
Fornage M
Mahajan A
Pedersen O
Kähönen M
Huppertz C
Glaser S
Klein RJ
Thorand B
Grammer TB
Bouchard C
Corre T
Marques-Vidal PM
Jansson JO
Milaneschi Y
Hindorff L
Amin N
Scott RA
Pasko D
Kooperberg C
Bragg-Gresham JL
Sidney S
Kivimäki M
Ngwa JS
Chu AY
Gieger C
Barroso I
Magl R
Tammelin T
Borja JB
Eriksson J
Dorr M
Smith AV
Kooner JS
Busonero F
Faul JD
Bonnefond A
Luan J
Lakka TA
Kinnunen L
Boerwinkle E
Rose LM
Teumer A
Frayling TM
Juonala M
Abecasis GR
Lim E
Brage S
Demirkan A
North KE
McCarthy MI
Swift AJ
Oldehinkel AJ
Kristiansson K
Hernandez D
Stringham HM
Hottenga JJ
Eicher JD
Adair LS
Sternfeld B
Zhao JH
Bien S
Metspalu A
Ahmad S
Ohlsson C
Qi QB
Zubair N
Quaye L
Koistinen HA
James AL
Wild S
Snitker S
Holzapfel C
Justesen JM
Faerch K
Rankinen T
Scott WR
Whitfield JB
Hutri-Kähönen N
Winkler TW
Tan ST
Fu M
Strauch K
Kleber ME
Gong J
Huth C
Chasman DI
Cornelis M
Martin NG
van Vliet-Ostaptchouk JV
Peters U
Cheng YC
Kilpeläinen TO
Lim U
Tönjes A
Hui J
Kuusisto J
Huffman JE
Graff M
Lehtimaki T
Raitakari OT
Paternoster L
Porteous DJ
Hveem K
Young KL
Ebeling T
Rasmussen-Torvik LJ
Perez J
Hirschhorn JN
Heard-Costa NL
Järvelin MR
Harder MN
Marz W
Männistö S
Chambers JC
Smith JA
Marten J
Jackson AU
Fox CS
Hadley D
Komulainen P
Grarup N
Launer LJ
Chines PS
Linneberg A
Shuldiner AR
Sarzynski MA
Hallmans G
Bertoni AG
Silbernagel G
Cupples LA
Thuillier D
Ahluwalia TS
Strachan DP
Smith BH
Rivadeneira F
Mulas A
Sørensen TIA
Franks PW
Willemsen G
Van der Most PJ
Kvaløy K
Borecki IB
Liu YM
Huang J
Johansson A
Auvinen J
Kutalik Z
Völzke H
O'Connell JR
Savonen K
Penninx BWJH
Hayward C
de Geus EJC
Tuomilehto J
Ong KK
Uitterlinden AG
Peyser PA
Feitosa MF
Smith GD
Hastie ND
Rudan I
Kumari M
Rivera NV
Musk AW
Rawal R
van Duijn CM
Yengo L
Gyllensten U
Gudnason V
Boehnke M
Hocking LJ
Hassinen M
Zillikens MC
Wu Y
Nauck M
Renström F
Kardia SLR
Padmanabhan S
Havulinna AS
Stančáková A
Narisu N
Esko T
Balkau B
Beilby J
Palmer LJ
Eiriksdottir G
Peyrot WJ
Bonnycastle LL
Kuh D
Lyytikäinen LP
Zhao W
Marre M
Wong A
Pérusse L
Haiman CA
Puolijoki H
Nettleton JA
Müller-Nurasyid M
Polasek O
Navarro P
Laakso M
Hayes JE
Prokopenko I
Cucca F
Zhang WH
Bellis C
Barata L
Froguel P
Bergman RN
Tanaka T
Harald K
Delgado GE
PUBLIC LIBRARY SCIENCE
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042612551
https://urn.fi/URN:NBN:fi-fe2021042612551
Tiivistelmä
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by similar to 30% in physically active individuals compared to inactive individuals, we do not identify additional loci that are sensitive to PA. In additional genome-wide meta-analyses adjusting for PA and interaction with PA, we identify 11 novel adiposity loci, suggesting that accounting for PA or other environmental factors that contribute to variation in adiposity may facilitate gene discovery.
Kokoelmat
- Rinnakkaistallenteet [19207]