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Quantitative Analysis of Porous Silicon Nanoparticles Functionalization by 1H NMR

Li Jiachen; Shiqi Wang; Mäkilä Ermei; Santos Hélder A.; Xia Bing; Hirvonen Jouni; Moslova Karina; Salonen Jarno; Cheng Ruoyu

Quantitative Analysis of Porous Silicon Nanoparticles Functionalization by 1H NMR

Li Jiachen
Shiqi Wang
Mäkilä Ermei
Santos Hélder A.
Xia Bing
Hirvonen Jouni
Moslova Karina
Salonen Jarno
Cheng Ruoyu
Katso/Avaa
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American Chemical Society
doi:10.1021/acsbiomaterials.1c00440
URI
https://pubs.acs.org/doi/10.1021/acsbiomaterials.1c00440
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021093047966
Tiivistelmä

Porous silicon (PSi) nanoparticles have been applied in various fields, such as catalysis, imaging, and biomedical applications, because of their large specific surface area, easily modifiable surface chemistry, biocompatibility, and biodegradability. For biomedical applications, it is important to precisely control the surface modification of PSi-based materials and quantify the functionalization density, which determines the nanoparticle’s behavior in the biological system. Therefore, we propose here an optimized solution to quantify the functionalization groups on PSi, based on the nuclear magnetic resonance (NMR) method by combining the hydrolysis with standard 1H NMR experiments. We optimized the hydrolysis conditions to degrade the PSi, providing mobility to the molecules for NMR detection. The NMR parameters were also optimized by relaxation delay and the number of scans to provide reliable NMR spectra. With an internal standard, we quantitatively analyzed the surficial amine groups and their sequential modification of polyethylene glycol. Our investigation provides a reliable, fast, and straightforward method in quantitative analysis of the surficial modification characterization of PSi requiring a small amount of sample.

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