Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl
Laine K; Neuvonen PJ; Olkkola KT; Neuvonen M; Saari TI
Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl
Laine K
Neuvonen PJ
Olkkola KT
Neuvonen M
Saari TI
SPRINGER
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042715303
https://urn.fi/URN:NBN:fi-fe2021042715303
Tiivistelmä
Conclusion Both voriconazole and fluconazole delay the elimination of fentanyl significantly. Caution should be exercised, especially in patients who are given voriconazole or fluconazole during long-lasting fentanyl treatment, because insidiously elevated fentanyl concentration may lead to respiratory depression.
Kokoelmat
- Rinnakkaistallenteet [19207]