Näytä suppeat kuvailutiedot

Clinical and biochemical signs of polycystic ovary syndrome in young women born preterm

Eriksson Johan; Järvelin Marjo-Riitta; Kajantie Eero; Matinolli Hanna-Maria; Morin-Papunen Laure; Mustaniemi Sanna; Paalanne Marika; Tikanmäki Marjaana; Vääräsmäki Marja; Wehkalampi Karoliina

dc.contributor.authorEriksson Johan
dc.contributor.authorJärvelin Marjo-Riitta
dc.contributor.authorKajantie Eero
dc.contributor.authorMatinolli Hanna-Maria
dc.contributor.authorMorin-Papunen Laure
dc.contributor.authorMustaniemi Sanna
dc.contributor.authorPaalanne Marika
dc.contributor.authorTikanmäki Marjaana
dc.contributor.authorVääräsmäki Marja
dc.contributor.authorWehkalampi Karoliina
dc.date.accessioned2022-10-27T11:59:19Z
dc.date.available2022-10-27T11:59:19Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/156421
dc.description.abstract<p>Abstract</p><p>Objective<br>It has been suggested that adverse early life exposures increase the risk of developing polycystic ovary syndrome (PCOS) in later life. We hypothesized that women born preterm would have more biochemical and clinical signs of PCOS than women born at term.</p><p>Design<br>The ESTER Preterm Birth Study participants were born in Northern Finland and identified from the Northern Finland Birth Cohort and the Finnish Medical Birth Register. Altogether, 74 women born very or moderately preterm (<34 gestational weeks, VMPT), 127 born late preterm (at 34–36 weeks, LPT), and 184 born full term (≥37 weeks, controls) were included in the analysis (mean age: 23.2 years).</p><p>Methods<br>We measured serum total testosterone and sex hormone-binding globulin (SHBG) and calculated the free androgen index (FAI). PCOS according to the clinical and biochemical signs was defined either as hirsutism and oligoamenorrhea (via questionnaire) or as oligoamenorrhea and elevated testosterone levels (>2.4 nmol/L).</p><p>Results<br>Women born VMPT/LPT exhibited 33.0% (8.7, 62.8)/16.4% (−2.0, 38.1) higher testosterone, 28.5% (5.3, 45.9)/24.1% (5.6, 38.9) lower SHBG levels, and 64.6% (19.4, 127.1)/42.5% (11.1, 82.9) higher FAI than controls after adjusting for age and recruitment cohort, maternal BMI, smoking, and pregnancy disorders, parental education, history of hypertension, diabetes, myocardial infarction or stroke, and subject’s birth weight s.d. Odds ratios for having PCOS were 1.67 (0.44, 6.23)/3.11 (1.26, 7.70).</p><p>Conclusions<br>Women born preterm have a more hyperandrogenic hormonal profile, and those born LPT are approximately three times more likely at risk to have PCOS compared to women born at term.<br></p>
dc.language.isoen
dc.publisherEuropean society of endocrinology
dc.titleClinical and biochemical signs of polycystic ovary syndrome in young women born preterm
dc.identifier.urlhttps://eje.bioscientifica.com/view/journals/eje/185/2/EJE-20-1462.xml
dc.identifier.urnURN:NBN:fi-fe2021093047956
dc.relation.volume185
dc.contributor.organizationfi=PÄÄT INVEST Lippulaiva Lastenpsykiatria|en=PÄÄT INVEST Flagship Child Psychiatry |
dc.contributor.organizationfi=lastenpsykiatrian tutkimuskeskus|en=Lastenpsykiatrian tutkimuskeskus|
dc.contributor.organization-code2603023
dc.contributor.organization-code2607326
dc.converis.publication-id66684804
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/66684804
dc.format.pagerange279
dc.format.pagerange288
dc.identifier.eissn1479-683X
dc.identifier.jour-issn0804-4643
dc.okm.affiliatedauthorMatinolli, Hanna-Maria
dc.okm.discipline3123 Gynaecology and paediatricsen_GB
dc.okm.discipline3123 Naisten- ja lastentauditfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countryUnited Kingdomen_GB
dc.publisher.countryBritanniafi_FI
dc.publisher.country-codeGB
dc.relation.doi10.1530/EJE-20-1462
dc.relation.ispartofjournalEuropean Journal of Endocrinology
dc.relation.issue2
dc.year.issued2021


Aineistoon kuuluvat tiedostot

Thumbnail

Aineisto kuuluu seuraaviin kokoelmiin

Näytä suppeat kuvailutiedot