Hyppää sisältöön
    • Suomeksi
    • In English
  • Suomeksi
  • In English
  • Kirjaudu
Näytä aineisto 
  •   Etusivu
  • 3. UTUCris-artikkelit
  • Rinnakkaistallenteet
  • Näytä aineisto
  •   Etusivu
  • 3. UTUCris-artikkelit
  • Rinnakkaistallenteet
  • Näytä aineisto
JavaScript is disabled for your browser. Some features of this site may not work without it.

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

de Mutsert R; Kritchevsky SB; Heng CK; Vollenweider P; Howard BV; Wong TY; Samani NJ; Tai ES; Dorajoo R; Wu TC; He J; Jonas JB; Scott J; Guo XQ; Li CW; Rose LM; Bowden DW; Gasparini P; Alver M; Kahonen M; Rice K; van Duijn CM; Khor CC; Fau JD; Scott RA; Bartz TM; Sidney S; Fuentes LDL; Warren HR; Ehret G; Smith JA; Penninx BWJH; Wang YJ; Froguel P; Zonderman AB; Lehtimaki T; Hallmans G; Campbell A; Bin Wei W; Province MA; Kooperberg C; Palmas W; Leander K; Kubo M; Stancakova A; Zhu XF; Rankinen T; Boehnke M; Mohlke KL; Elliott P; Watkins H; Raffel LJ; Tham YC; Harris TB; Hagenaars SP; Poiasek O; Nelson CP; Wickremasinghe AR; Vojinovic D; Aschard H; Gieger C; Smith AV; Scott WR; Yu CZ; Winkler TW; O'Connell JR; Koh WP; Cheng CY; Munroe PB; Kutalik Z; Porteous DJ; Marten J; Laurie CC; Heikkinen S; Vitart V; Brumat M; Charumathi S; Ntalla I; Lewis CE; Afaq S; van Dam RM; Gao C; Varga TV; Broeckel U; Magnusson PKE; Feitosa MF; Boerwinkle E; Uitterlinden AG; Deng X; Loh M; Ware EB; Rao DC; Lakka TA; Snieder H; Louie T; Komulainen P; Lin S; Wang LH; Eppinga RN; Perls T; Brown M; Manning AK; Gudnason V; McKenzie CA; Mook-Kanamori DO; Yuan JM; Meitinger T; Hirata M; Yao J; Fisher V; Hartwig FP; Horta BL; Sims M; Burke GL; Momozawa Y; Waldenberger M; Morrison AC; Chambers JC; Li YZ; Eaton CB; Richard MA; Amin N; Freedman BI; Franks PW; Robino A; Langenberg C; Teo YY; Schmidt CO; Takeuchi F; Farrall M; Norris JM; Chakravarti A; Borecki I; Padmanabhan S; Chen X; Sim XL; Ridker PM; Franco OH; Rosendaal FR; Magi R; Liu YM; Launer LJ; van der Harst P; Bielak LF; Rueedi R; Roll K; Zheng W; Wagenknecht LE; Rauramaa R; Harris SE; Felix SB; Weir DR; Sofer T; Caulfield MJ; Kamatani Y; Nolte IM; van der Most PJ; Langefeld CD; Peyser PA; Tan NYQ; Franceschini N; Peters A; Said MA; Nalls MA; Kraja AT; Raitakari OT; Gao H; John U; Gigante B; Christensen K; Divers J; Kuusisto J; Fornage M; Katsuya T; Poulter N; Fox ER; Starr JM; Chen YDI; Milaneschi Y; Evangelou E; Rotter JI; Deary IJ; Luan J; Wen WQ; Liu JJ; Kato N; Kilpelainen TO; Evans MK; Kooner JS; Wojczynski MK; Wang YX; Milani L; Arking DE; Gandin I; Hsu FC; Rotimi CN; Schreiner PJ; Becker DM; Tang H; Tayo BO; Gauderman WJ; Sitlani CM; Schupf N; Weiss S; Gu DF; Laakso M; Stringham HM; Palmer ND; Williams C; Wareham NJ; Kuhnel B; Musani SK; Levy D; Cai QY; Goel A; Sotoodehnia N; Friedlander Y; Ghanbari M; Zhao W; Ding J; Liu JM; Canouil M; Psaty BM; Pereira AC; Lehne B; Brown MR; Shu XO; Riaz M; Connell JM; Chasman DI; Kelly TN; Cupples LA; Taylor KD; de Silva HJ; Chai JF; Duan Q; Krieger JE; Strauch K; Kasturiratne A; Turner ST; Lohman KK; Forouhi NG; He MI; Zhang WH; Horimoto ARVR; Amini M; Ikram MA; Tajuddin SM; Esko T; Gu CC; Jackson AU; Sever PS; Kardia SLR; Noordam R; Pedersen NL; Correa A; Metspalu A; Hagemeijer Y; Matoba N; Boissel M; Forrester T; Hayward C; Shi Y; Bentley AR; Oldehinkel AJ; Sung YJ; Study LC; Schwander K; Laguzzi F; Bouchard C; Aung T; Yanek LR; Zhao JH

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

de Mutsert R
Kritchevsky SB
Heng CK
Vollenweider P
Howard BV
Wong TY
Samani NJ
Tai ES
Dorajoo R
Wu TC
He J
Jonas JB
Scott J
Guo XQ
Li CW
Rose LM
Bowden DW
Gasparini P
Alver M
Kahonen M
Rice K
van Duijn CM
Khor CC
Fau JD
Scott RA
Bartz TM
Sidney S
Fuentes LDL
Warren HR
Ehret G
Smith JA
Penninx BWJH
Wang YJ
Froguel P
Zonderman AB
Lehtimaki T
Hallmans G
Campbell A
Bin Wei W
Province MA
Kooperberg C
Palmas W
Leander K
Kubo M
Stancakova A
Zhu XF
Rankinen T
Boehnke M
Mohlke KL
Elliott P
Watkins H
Raffel LJ
Tham YC
Harris TB
Hagenaars SP
Poiasek O
Nelson CP
Wickremasinghe AR
Vojinovic D
Aschard H
Gieger C
Smith AV
Scott WR
Yu CZ
Winkler TW
O'Connell JR
Koh WP
Cheng CY
Munroe PB
Kutalik Z
Porteous DJ
Marten J
Laurie CC
Heikkinen S
Vitart V
Brumat M
Charumathi S
Ntalla I
Lewis CE
Afaq S
van Dam RM
Gao C
Varga TV
Broeckel U
Magnusson PKE
Feitosa MF
Boerwinkle E
Uitterlinden AG
Deng X
Loh M
Ware EB
Rao DC
Lakka TA
Snieder H
Louie T
Komulainen P
Lin S
Wang LH
Eppinga RN
Perls T
Brown M
Manning AK
Gudnason V
McKenzie CA
Mook-Kanamori DO
Yuan JM
Meitinger T
Hirata M
Yao J
Fisher V
Hartwig FP
Horta BL
Sims M
Burke GL
Momozawa Y
Waldenberger M
Morrison AC
Chambers JC
Li YZ
Eaton CB
Richard MA
Amin N
Freedman BI
Franks PW
Robino A
Langenberg C
Teo YY
Schmidt CO
Takeuchi F
Farrall M
Norris JM
Chakravarti A
Borecki I
Padmanabhan S
Chen X
Sim XL
Ridker PM
Franco OH
Rosendaal FR
Magi R
Liu YM
Launer LJ
van der Harst P
Bielak LF
Rueedi R
Roll K
Zheng W
Wagenknecht LE
Rauramaa R
Harris SE
Felix SB
Weir DR
Sofer T
Caulfield MJ
Kamatani Y
Nolte IM
van der Most PJ
Langefeld CD
Peyser PA
Tan NYQ
Franceschini N
Peters A
Said MA
Nalls MA
Kraja AT
Raitakari OT
Gao H
John U
Gigante B
Christensen K
Divers J
Kuusisto J
Fornage M
Katsuya T
Poulter N
Fox ER
Starr JM
Chen YDI
Milaneschi Y
Evangelou E
Rotter JI
Deary IJ
Luan J
Wen WQ
Liu JJ
Kato N
Kilpelainen TO
Evans MK
Kooner JS
Wojczynski MK
Wang YX
Milani L
Arking DE
Gandin I
Hsu FC
Rotimi CN
Schreiner PJ
Becker DM
Tang H
Tayo BO
Gauderman WJ
Sitlani CM
Schupf N
Weiss S
Gu DF
Laakso M
Stringham HM
Palmer ND
Williams C
Wareham NJ
Kuhnel B
Musani SK
Levy D
Cai QY
Goel A
Sotoodehnia N
Friedlander Y
Ghanbari M
Zhao W
Ding J
Liu JM
Canouil M
Psaty BM
Pereira AC
Lehne B
Brown MR
Shu XO
Riaz M
Connell JM
Chasman DI
Kelly TN
Cupples LA
Taylor KD
de Silva HJ
Chai JF
Duan Q
Krieger JE
Strauch K
Kasturiratne A
Turner ST
Lohman KK
Forouhi NG
He MI
Zhang WH
Horimoto ARVR
Amini M
Ikram MA
Tajuddin SM
Esko T
Gu CC
Jackson AU
Sever PS
Kardia SLR
Noordam R
Pedersen NL
Correa A
Metspalu A
Hagemeijer Y
Matoba N
Boissel M
Forrester T
Hayward C
Shi Y
Bentley AR
Oldehinkel AJ
Sung YJ
Study LC
Schwander K
Laguzzi F
Bouchard C
Aung T
Yanek LR
Zhao JH
Katso/Avaa
Publisher's version (3.027Mb)
Lataukset: 

PUBLIC LIBRARY SCIENCE
doi:10.1371/journal.pone.0198166
Näytä kaikki kuvailutiedot
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042719468
Tiivistelmä
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucleotide variant (SNV)-alcohol consumption interactions. In Stage 1, genome-wide discovery meta-analyses in approximate to 131 K individuals across several ancestry groups yielded 3,514 SNVs (245 loci) with suggestive evidence of association (P <1.0 x 10(-5)). In Stage 2, these SNVs were tested for independent external replication in individuals across multiple ancestries. We identified and replicated (at Bonferroni correction threshold) five novel BP loci (380 SNVs in 21 genes) and 49 previously reported BP loci (2,159 SNVs in 109 genes) in European ancestry, and in multi-ancestry meta-analyses (P < 5.0 x 10(-8)). For African ancestry samples, we detected 18 potentially novel BP loci (P< 5.0 x 10(-8)) in Stage 1 that warrant further replication. Additionally, correlated meta-analysis identified eight novel BP loci (11 genes). Several genes in these loci (e.g., PINX1, GATA4, BLK, FTO and GABBR2 have been previously reported to be associated with alcohol consumption. These findings provide insights into the role of alcohol consumption in the genetic architecture of hypertension.
Kokoelmat
  • Rinnakkaistallenteet [19207]

Turun yliopiston kirjasto | Turun yliopisto
julkaisut@utu.fi | Tietosuoja | Saavutettavuusseloste
 

 

Tämä kokoelma

JulkaisuajatTekijätNimekkeetAsiasanatTiedekuntaLaitosOppiaineYhteisöt ja kokoelmat

Omat tiedot

Kirjaudu sisäänRekisteröidy

Turun yliopiston kirjasto | Turun yliopisto
julkaisut@utu.fi | Tietosuoja | Saavutettavuusseloste