dc.contributor.author | Chunlei Han | |
dc.contributor.author | Xua Sha | |
dc.contributor.author | Qingtao Qiu | |
dc.contributor.author | Yong Yin | |
dc.contributor.author | Guanzhong Gong | |
dc.date.accessioned | 2022-10-27T12:08:27Z | |
dc.date.available | 2022-10-27T12:08:27Z | |
dc.identifier.uri | https://www.utupub.fi/handle/10024/156551 | |
dc.description.abstract | Objective Previous studies have shown that increased cardiac uptake of(18)F-fluorodeoxyglucose (FDG) on positron emission tomography (PET) may be an indicator of myocardial injury after radiotherapy (RT). The primary objective of this study was to quantify cardiac subvolume dosimetry and(18)F-FDG uptake on oncologic PET using a 17-segment model of the left ventricle (LV) and to identify dose limits related to changes in cardiac(18)F-FDG uptake after RT. Methods Twenty-four esophageal cancer (EC) patients who underwent consecutive oncologic(18)F-FDG PET/CT scans at baseline and post-RT were enrolled in this study. The radiation dose and the(18)F-FDG uptake were quantitatively analyzed based on a 17-segment model. The(18)F-FDG uptake and doses to the basal, middle and apical regions, and the changes in the(18)F-FDG uptake for different dose ranges were analyzed. <div>Results A heterogeneous dose distribution was observed, and the basal region received a higher median mean dose (18.36 Gy) than the middle and apical regions (5.30 and 2.21 Gy, respectively). Segments 1, 2, 3, and 4 received the highest doses, all of which were greater than 10 Gy. Three patterns were observed for the myocardial(18)F-FDG uptake in relation to the radiation dose before and after RT: an increase (5 patients), a decrease (13 patients), and no change (6 patients). In a pairing analysis, the(18)F-FDG uptake after RT decreased by 28.93 and 12.12% in the low-dose segments (0-10 Gy and 10-20 Gy, respectively) and increased by 7.24% in the high-dose segments (20-30 Gy). Conclusion The RT dose varies substantially within LV segments in patients receiving thoracic EC RT. Increased(18)F-FDG uptake in the myocardium after RT was observed for doses above 20 Gy.</div> | |
dc.language.iso | en | |
dc.publisher | FRONTIERS MEDIA SA | |
dc.title | Quantification of Myocardial Dosimetry and Glucose Metabolism Using a 17-Segment Model of the Left Ventricle in Esophageal Cancer Patients Receiving Radiotherapy | |
dc.identifier.urn | URN:NBN:fi-fe2021042824428 | |
dc.relation.volume | 10 | |
dc.contributor.organization | fi=tyks, vsshp|en=tyks, vsshp| | |
dc.contributor.organization | fi=PET perustoiminta|en=PET Basic Operations| | |
dc.contributor.organization-code | 2609810 | |
dc.converis.publication-id | 50339867 | |
dc.converis.url | https://research.utu.fi/converis/portal/Publication/50339867 | |
dc.identifier.eissn | 2234-943X | |
dc.identifier.jour-issn | 2234-943X | |
dc.okm.affiliatedauthor | Han, Chunlei | |
dc.okm.affiliatedauthor | Dataimport, tyks, vsshp | |
dc.okm.discipline | 3122 Syöpätaudit | fi_FI |
dc.okm.discipline | 3122 Cancers | en_GB |
dc.okm.internationalcopublication | international co-publication | |
dc.okm.internationality | International publication | |
dc.okm.type | Journal article | |
dc.publisher.country | Sveitsi | fi_FI |
dc.publisher.country | Switzerland | en_GB |
dc.publisher.country-code | CH | |
dc.relation.articlenumber | ARTN 1599 | |
dc.relation.doi | 10.3389/fonc.2020.01599 | |
dc.relation.ispartofjournal | Frontiers in Oncology | |
dc.year.issued | 2020 | |