Hyppää sisältöön
    • Suomeksi
    • In English
  • Suomeksi
  • In English
  • Kirjaudu
Näytä aineisto 
  •   Etusivu
  • 3. UTUCris-artikkelit
  • Rinnakkaistallenteet
  • Näytä aineisto
  •   Etusivu
  • 3. UTUCris-artikkelit
  • Rinnakkaistallenteet
  • Näytä aineisto
JavaScript is disabled for your browser. Some features of this site may not work without it.

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Lyytikäinen LP; Kähönen M; Havulinna AS; Maan AC; Brody JA; Olesen M; Bis JC; Schramm K; Isaacs A; Rudan I; Yao J; Gögele M; De Grandi A; Ryan K; Shuldiner AR; Gustav Smith J; Kooperberg C; Van Duijvenboden S; Sinagra G; Benjamin EJ; Kerr KF; Felix SB; Cucca F; Lin HJ; Lin H; Campbell H; Thorolfsdottir RB; Stefansson K; Boutin T; Aeschbacher S; Ribeiro ALP; Arnar DO; Polasek O; Taylor KD; Warren HR; Nelson CP; Wilson JF; Lima-Costa MF; Meitinger T; Assa S; Rice K; Souza RP; Mei H; Levy D; Heckbert SR; Harris TB; Smith AV; Morris AP; Montasser ME; Lambiase PD; Lubitz SA; Mishra PP; Ntalla I; Raitakari OT; Benjamin Shoemaker M; Soliman EZ; Seyerle AA; Concas MP; Barnes CLK; Sotoodehnia N; Noordam R; Joshi PK; Haessler J; Kolcic I; Gudnason V; Jula A; Huang PL; Gasparini P; van Duijn CM; London B; Reiner AP; Völker U; Mook-Kanamori DO; Kääb S; Del Greco M F; Thorleifsson G; Lunetta KL; Cutler MJ; Ellinor PT; O'Connell JR; Spector TD; Newton-Cheh CH; van den Berg ME; Uitterlinden A; Weiss S; de Mutsert R; Dominiczak A; Conen D; Salomaa V; Gudbjartsson DF; Wouter Jukema J; Thériault S; Munroe PB; Nikus K; Launer LJ; Sulem P; Strauch K; Rotter JI; Mahajan A; Giedraitis V; Cranley JJ; Riaz MB; Barnes MR; Tarasov KV; Psaty BM; Guo X; Thorsteinsdottir U; Gogarten SM; Stricker BH; Sveinbjornsson G; Fuchsberger C; Arking DE; Correa A; Ramirez J; Caulfield MJ; Choi SH; Smith BH; Boerwinkle E; Peters U; Ingelsson E; Qian Y; Marten J; Risch L; Avery CL; Araujo NM; Weng LC; Sääksjärvi K; Lakatta EG; Porteous DJ; Foco L; Dörr M; Tucker NR; van de Vegte YJ; Macfarlane PW; Kors JA; Ehret GB; Mifsud B; Roden DM; Mangino M; Ford I; Jamshidi Y; Cartwright JH; Lind L; Yldau van der Ende M; Pramstaller PP; Verweij N; Pattaro C; Nadkarni GN; Biggs ML; Lehtimäki T; Murray AD; Laurie CC; Whitsel EA; Tinker A; Hayward C; Alonso A; Cook JP; Samani NJ; Wilson J; Preuss MH; Loos RJF; Roselli C; Holm H; van der Harst P; Hicks AA; Trompet S; Chaffin MD; Orini M; Padmanabhan S; Sundström J; Bottinger EP; Waldenberger M; Jackson RD; Rienstra M; Ulivi S; Müller-Nurasyid M; Stilp A; Fatkin D; Mononen N; Abdullah Said M; Tarazona-Santos E; Peters A; Hall AW; Lindgren CM; Ding J; Hutri-Kähönen N; Sinner MF

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Lyytikäinen LP
Kähönen M
Havulinna AS
Maan AC
Brody JA
Olesen M
Bis JC
Schramm K
Isaacs A
Rudan I
Yao J
Gögele M
De Grandi A
Ryan K
Shuldiner AR
Gustav Smith J
Kooperberg C
Van Duijvenboden S
Sinagra G
Benjamin EJ
Kerr KF
Felix SB
Cucca F
Lin HJ
Lin H
Campbell H
Thorolfsdottir RB
Stefansson K
Boutin T
Aeschbacher S
Ribeiro ALP
Arnar DO
Polasek O
Taylor KD
Warren HR
Nelson CP
Wilson JF
Lima-Costa MF
Meitinger T
Assa S
Rice K
Souza RP
Mei H
Levy D
Heckbert SR
Harris TB
Smith AV
Morris AP
Montasser ME
Lambiase PD
Lubitz SA
Mishra PP
Ntalla I
Raitakari OT
Benjamin Shoemaker M
Soliman EZ
Seyerle AA
Concas MP
Barnes CLK
Sotoodehnia N
Noordam R
Joshi PK
Haessler J
Kolcic I
Gudnason V
Jula A
Huang PL
Gasparini P
van Duijn CM
London B
Reiner AP
Völker U
Mook-Kanamori DO
Kääb S
Del Greco M F
Thorleifsson G
Lunetta KL
Cutler MJ
Ellinor PT
O'Connell JR
Spector TD
Newton-Cheh CH
van den Berg ME
Uitterlinden A
Weiss S
de Mutsert R
Dominiczak A
Conen D
Salomaa V
Gudbjartsson DF
Wouter Jukema J
Thériault S
Munroe PB
Nikus K
Launer LJ
Sulem P
Strauch K
Rotter JI
Mahajan A
Giedraitis V
Cranley JJ
Riaz MB
Barnes MR
Tarasov KV
Psaty BM
Guo X
Thorsteinsdottir U
Gogarten SM
Stricker BH
Sveinbjornsson G
Fuchsberger C
Arking DE
Correa A
Ramirez J
Caulfield MJ
Choi SH
Smith BH
Boerwinkle E
Peters U
Ingelsson E
Qian Y
Marten J
Risch L
Avery CL
Araujo NM
Weng LC
Sääksjärvi K
Lakatta EG
Porteous DJ
Foco L
Dörr M
Tucker NR
van de Vegte YJ
Macfarlane PW
Kors JA
Ehret GB
Mifsud B
Roden DM
Mangino M
Ford I
Jamshidi Y
Cartwright JH
Lind L
Yldau van der Ende M
Pramstaller PP
Verweij N
Pattaro C
Nadkarni GN
Biggs ML
Lehtimäki T
Murray AD
Laurie CC
Whitsel EA
Tinker A
Hayward C
Alonso A
Cook JP
Samani NJ
Wilson J
Preuss MH
Loos RJF
Roselli C
Holm H
van der Harst P
Hicks AA
Trompet S
Chaffin MD
Orini M
Padmanabhan S
Sundström J
Bottinger EP
Waldenberger M
Jackson RD
Rienstra M
Ulivi S
Müller-Nurasyid M
Stilp A
Fatkin D
Mononen N
Abdullah Said M
Tarazona-Santos E
Peters A
Hall AW
Lindgren CM
Ding J
Hutri-Kähönen N
Sinner MF
Katso/Avaa
Publisher's version (3.381Mb)
Lataukset: 

Nature Publishing Group
doi:10.1038/s41467-020-15706-x
Näytä kaikki kuvailutiedot
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042822286
Tiivistelmä

The electrocardiographic PR interval reflects atrioventricular
conduction, and is associated with conduction abnormalities, pacemaker
implantation, atrial fibrillation (AF), and cardiovascular mortality.
Here we report a multi-ancestry (N = 293,051) genome-wide association
meta-analysis for the PR interval, discovering 202 loci of which 141
have not previously been reported. Variants at identified loci increase
the percentage of heritability explained, from 33.5% to 62.6%. We
observe enrichment for cardiac muscle developmental/contractile and
cytoskeletal genes, highlighting key regulation processes for
atrioventricular conduction. Additionally, 8 loci not previously
reported harbor genes underlying inherited arrhythmic syndromes and/or
cardiomyopathies suggesting a role for these genes in cardiovascular
pathology in the general population. We show that polygenic
predisposition to PR interval duration is an endophenotype for
cardiovascular disease, including distal conduction disease, AF, and
atrioventricular pre-excitation. These findings advance our
understanding of the polygenic basis of cardiac conduction, and the
genetic relationship between PR interval duration and cardiovascular
disease.

Kokoelmat
  • Rinnakkaistallenteet [19207]

Turun yliopiston kirjasto | Turun yliopisto
julkaisut@utu.fi | Tietosuoja | Saavutettavuusseloste
 

 

Tämä kokoelma

JulkaisuajatTekijätNimekkeetAsiasanatTiedekuntaLaitosOppiaineYhteisöt ja kokoelmat

Omat tiedot

Kirjaudu sisäänRekisteröidy

Turun yliopiston kirjasto | Turun yliopisto
julkaisut@utu.fi | Tietosuoja | Saavutettavuusseloste