Vimentin Suppresses Inflammation and Tumorigenesis in the Mouse Intestine
Mohanasundaram Ponnuswamy; Chen Zhi; Sultana Giulia; Eriksson John E.; Misiorek Julia O.; Lindström Michelle; Toivola Diana M.; Asghar Muhammad Naheem; Jiu Yaming; Wang Linglu; Cheng Fang; Chen Hongbo
Vimentin Suppresses Inflammation and Tumorigenesis in the Mouse Intestine
Mohanasundaram Ponnuswamy
Chen Zhi
Sultana Giulia
Eriksson John E.
Misiorek Julia O.
Lindström Michelle
Toivola Diana M.
Asghar Muhammad Naheem
Jiu Yaming
Wang Linglu
Cheng Fang
Chen Hongbo
FRONTIERS MEDIA SA
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022081153787
https://urn.fi/URN:NBN:fi-fe2022081153787
Tiivistelmä
Vimentin has been implicated in wound healing, inflammation, and cancer, but its functional contribution to intestinal diseases is poorly understood. To study how vimentin is involved during tissue injury and repair of simple epithelium, we induced colonic epithelial cell damage in the vimentin null (Vim(-/-)) mouse model. Vim(-/-) mice challenged with dextran sodium sulfate (DSS) had worse colitis manifestations than wild-type (WT) mice. Vim(-/-) colons also produced more reactive oxygen and nitrogen species, possibly contributing to the pathogenesis of gut inflammation and tumorigenesis than in WT mice. We subsequently describe that CD11b(+) macrophages served as the mainly cellular source of reactive oxygen species (ROS) production via vimentin-ROS-pSTAT3-interleukin-6 inflammatory pathways. Further, we demonstrated that Vim(-/-) mice did not develop colitis-associated cancer model upon DSS treatment spontaneously but increased tumor numbers and size in the distal colon in the azoxymethane/DSS model comparing with WT mice. Thus, vimentin has a crucial role in protection from colitis induction and tumorigenesis of the colon.
Kokoelmat
- Rinnakkaistallenteet [19207]