White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial
Liu Yawu; FINGER study group; Kemppainen Nina; Levälahti Esko; Strandberg Timo; Ngandu Tiia; Stephen Ruth; Solomon Alina; Parkkola Riitta; Kivipelto Miia; Soininen Hilkka; Rinne Juha O.; Antikainen Riitta
White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial
Liu Yawu; FINGER study group
Kemppainen Nina
Levälahti Esko
Strandberg Timo
Ngandu Tiia
Stephen Ruth
Solomon Alina
Parkkola Riitta
Kivipelto Miia
Soininen Hilkka
Rinne Juha O.
Antikainen Riitta
IOS PRESS
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042822491
https://urn.fi/URN:NBN:fi-fe2021042822491
Tiivistelmä
Background: Early pathological changes in white matter microstructure can be studied using the diffusion tensor imaging (DTI). It is not only important to study these subtle pathological changes leading to cognitive decline, but also to ascertain how an intervention would impact the white matter microstructure and cognition in persons at-risk of dementia.Objectives: To study the impact of a multidomain lifestyle intervention on white matter and cognitive changes during the 2-year Finnish Geriatric Intervention Study to prevent Cognitive Impairment and Disability (FINGER), a randomized controlled trial in at-risk older individuals (age 60-77 years) from the general population.Methods: This exploratory study consisted of a subsample of 60 FINGER participants. Participants were randomized to either a multidomain intervention (diet, exercise, cognitive training, and vascular risk management, n = 34) or control group (general health advice, n = 26). All underwent baseline and 2-year brain DTI. Changes in fractional anisotropy (FA), diffusivity along domain (F1) and non-domain (F2) diffusion orientations, mean diffusivity (MD), axial diffusivity (AxD), radial diffusivity (RD), and their correlations with cognitive changes during the 2-year multidomain intervention were analyzed.Results: FA decreased, and cognition improved more in the intervention group compared to the control group (p < 0.05), with no significant intergroup differences for changes in F1, F2, MD, AxD, or RD. The cognitive changes were significantly positively related to FA change, and negatively related to RD change in the control group, but not in the intervention group.Conclusion: The 2-year multidomain FINGER intervention may modulate white matter microstructural alterations.
Kokoelmat
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