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Long-term outcomes after coronary artery bypass surgery in patients with rheumatoid arthritis

Malmberg Markus; Palomäki Antti; Kytö Ville; Rautava Päivi; Sipilä Jussi OT; Gunn Jarmo

Long-term outcomes after coronary artery bypass surgery in patients with rheumatoid arthritis

Malmberg Markus
Palomäki Antti
Kytö Ville
Rautava Päivi
Sipilä Jussi OT
Gunn Jarmo
Katso/Avaa
Publisher's pdf (1.744Mb)
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TAYLOR & FRANCIS LTD
doi:10.1080/07853890.2021.1969591
URI
https://doi.org/10.1080/07853890.2021.1969591
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021100750217
Tiivistelmä

Objective: To investigate the long-term outcomes of coronary artery bypass grafting surgery (CABG) in patients with rheumatoid arthritis (RA).

Methods: Patients with RA (n = 378) were retrospectively compared to patients without RA (n = 7560), all treated with CABG in a multicentre, population-based cohort register study in Finland. The outcomes were studied with propensity score-matching adjustment for baseline features. The median follow-up was 9.7 years.

Results: Diagnosis of RA was associated with an increased risk of mortality after CABG compared to patients without RA (HR 1.50; CI 1.28-1.77; p < .0001). In addition, patients with RA were in higher risk of myocardial infarction during the follow-up period (HR 1.61; CI 1.28-2.04; p < .0001). Cumulative rate of repeated revascularization after CABG was 14.4% in RA patients and 12.0% in control patients (p = .060). Duration of RA before CABG (p = .011) and preoperative corticosteroid usage in RA (p = .041) were independently associated with higher mortality after CABG. There were no differences between the study groups in 30-d mortality or in the post-operative usage of cardiovascular medications.

Conclusions: RA is independently associated with worse prognosis in coronary artery disease treated with CABG. Preoperative corticosteroid use and longer RA disease duration are additional risk factors for mortality.Key messagesPatients with rheumatoid arthritis (RA) have impaired long-term outcomes after coronary artery bypass surgery (CABG).Glucocorticoid use before CABG and duration of RA are associated with higher mortality.Special attention should be paid in secondary prevention of cardiovascular disease in RA patients after CABG.

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