Metabolite-related dietary patterns and the development of islet autoimmunity
Ulla Uusitalo; Randi K. Johnson; Oliver Fiehn; Jeffrey Krischer; Tessa Crume; Jin-Xiong She; Katerina Kechris; Åke Lernmark; Brian C . DeFelice; Beena Akolkar; Marci Sontag; Suvi M. Virtanen; Anette-G. Ziegler; Jorma Toppari; Jill M. Norris; & The TEDDY Study Group; Marian Rewers; Lauren Vanderlinden; William Hagopian; Andreas Beyerlein
Metabolite-related dietary patterns and the development of islet autoimmunity
Ulla Uusitalo
Randi K. Johnson
Oliver Fiehn
Jeffrey Krischer
Tessa Crume
Jin-Xiong She
Katerina Kechris
Åke Lernmark
Brian C . DeFelice
Beena Akolkar
Marci Sontag
Suvi M. Virtanen
Anette-G. Ziegler
Jorma Toppari
Jill M. Norris; & The TEDDY Study Group
Marian Rewers
Lauren Vanderlinden
William Hagopian
Andreas Beyerlein
NATURE PUBLISHING GROUP
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042822710
https://urn.fi/URN:NBN:fi-fe2021042822710
Tiivistelmä
The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in theYoung) study. We created dietary patterns reflecting pre-IA metabolite differences between groups and examined their association with IA. Secondary outcomes included IA cases positive for multiple autoantibodies (mAb+). The association of 853 plasma metabolites with outcomes was tested at seroconversion to IA, just prior to seroconversion, and during infancy. Key compounds in enriched metabolite sets were used to create dietary patterns reflecting metabolite composition, which were then tested for association with outcomes in the nested case-control subset and the full TEDDY cohort. Unsaturated phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, glucosylceramides, and phospholipid ethers in infancy were inversely associated with mAb+ risk, while dicarboxylic acids were associated with an increased risk. An infancy dietary pattern representing higher levels of unsaturated phosphatidylcholines and phospholipid ethers, and lower sphingomyelins was protective for mAb+ in the nested case-control study only. Characterization of this high-risk infant metabolomics profile may help shape the future of early diagnosis or prevention efforts.
Kokoelmat
- Rinnakkaistallenteet [19207]