Näytä suppeat kuvailutiedot

Impact of Ideal Cardiovascular Health in Childhood on the Retinal Microvasculature in Midadulthood: Cardiovascular Risk in Young Finns Study

Tomi T. Laitinen; Alun Hughes; Matthew D. Campbell; Terho Lehtimäki; Katja Pahkala; Robyn J. Tapp; Tien Y. Wong; Nina Hutri-Kähönen; Mika Kähönen; Olli T. Raitakari; Markus Juonala

dc.contributor.authorTomi T. Laitinen
dc.contributor.authorAlun Hughes
dc.contributor.authorMatthew D. Campbell
dc.contributor.authorTerho Lehtimäki
dc.contributor.authorKatja Pahkala
dc.contributor.authorRobyn J. Tapp
dc.contributor.authorTien Y. Wong
dc.contributor.authorNina Hutri-Kähönen
dc.contributor.authorMika Kähönen
dc.contributor.authorOlli T. Raitakari
dc.contributor.authorMarkus Juonala
dc.date.accessioned2022-10-27T12:14:37Z
dc.date.available2022-10-27T12:14:37Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/157263
dc.description.abstract<p>Background-This study examined the association between ideal cardiovascular health (CVH) and the retinal microvasculature in midadulthood.</p><p>Methods and Results-The Cardiovascular Risk in Young Finns Study included children from 5 Finnish University cities, who were chosen randomly from the national population register. Participants ranged from 12 to 18 years in childhood (1986) and from 37 to 43 years in midadulthood (2011). Ideal CVH was defined according to the American Heart Association criteria. Retinal microvascular measures included diameters, lengths, length: diameter ratio, and tortuosity. From childhood to adulthood, fasting plasma glucose and blood pressure were significantly higher in those with impaired fasting glucose or diabetes mellitus. Childhood ideal CVH was negatively associated with adult arteriolar tortuosity (beta=-0.008; 95% confidence interval [CI], -0.01 to -0.003; P=0.001). Improved ideal CVH from childhood to adulthood was positively associated with adult arteriolar diameter (beta=0.122; 95% CI, 0.01-0.24; P=0.033) and negatively associated with adult length: diameter ratio (beta=-0.666; 95% CI, -1.25 to -0.08; P=0.026). When stratified by glucose metabolism, among those with diabetes mellitus and impaired fasting glucose, there was a negative association between childhood ideal CVH and adult venular diameter (diabetes mellitus: beta=-2.75; 95% CI, -5.46 to -0.04; P=0.047; impaired fasting glucose: beta=-2.13; 95% CI, -4.18 to -0.08; P=0.042).</p><p>Conclusions-This study is the first to comprehensively examine the impact of CVH from childhood to midadulthood on quantitative measures of the retinal microvasculature. Ideal CVH in childhood and improvement in CVH from childhood to adulthood appears to have a protective effect on the retinal microvasculature in those with, without, and at risk of diabetes mellitus.</p>
dc.language.isoen
dc.publisherWILEY
dc.titleImpact of Ideal Cardiovascular Health in Childhood on the Retinal Microvasculature in Midadulthood: Cardiovascular Risk in Young Finns Study
dc.identifier.urnURN:NBN:fi-fe2021042822749
dc.relation.volume7
dc.contributor.organizationfi=sisätautioppi|en=Internal Medicine|
dc.contributor.organizationfi=sydäntutkimuskeskus|en=Research Centre of Applied and Preventive Cardiovascular Medicine (CAPC)|
dc.contributor.organizationfi=tyks, vsshp|en=tyks, vsshp|
dc.contributor.organization-code2607318
dc.contributor.organization-code2607004
dc.converis.publication-id37818779
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/37818779
dc.identifier.jour-issn2047-9980
dc.okm.affiliatedauthorJuonala, Markus
dc.okm.affiliatedauthorDataimport, tyks, vsshp
dc.okm.affiliatedauthorRaitakari, Olli
dc.okm.affiliatedauthorLaitinen, Tomi
dc.okm.affiliatedauthorPahkala, Katja
dc.okm.discipline3121 Internal medicineen_GB
dc.okm.discipline3121 Sisätauditfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.publisher.countryUnited Statesen_GB
dc.publisher.countryYhdysvallat (USA)fi_FI
dc.publisher.country-codeUS
dc.relation.articlenumberARTN e009487
dc.relation.doi10.1161/JAHA.118.009487
dc.relation.ispartofjournalJournal of the American Heart Association
dc.relation.issue20
dc.year.issued2018


Aineistoon kuuluvat tiedostot

Thumbnail

Aineisto kuuluu seuraaviin kokoelmiin

Näytä suppeat kuvailutiedot