Middle age self-report risk score predicts cognitive functioning and dementia in 20–40 years
Kauko Heikkilä; Juha O. Rinne; Noora Lindgren; Jaakko Kaprio; Markku Koskenvuo; Eero Vuoksimaa
Middle age self-report risk score predicts cognitive functioning and dementia in 20–40 years
Kauko Heikkilä
Juha O. Rinne
Noora Lindgren
Jaakko Kaprio
Markku Koskenvuo
Eero Vuoksimaa
[Amsterdam] : Elsevier B.V., [2015]-
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042716056
Discussion: Self-report risk score predicted cognitive functioning and dementia risk 20–40 years later.
https://urn.fi/URN:NBN:fi-fe2021042716056
Tiivistelmä
Introduction: On the basis of the proxy measures of cognitive reserve, we created a middle age self-report risk score for early prediction of dementia.
Methods: We used a longitudinal population-based study of 2602 individuals with a replication sample (N = 1011). Risk score at a mean age of 47 years was based on questions on educational and occupational attainments. Cognitive status at a mean age of 74 was determined via two validated telephone instruments.
Results: The prevalence of dementia was 10% after a mean follow-up of 28 years. Risk score was a good predictor of dementia: area under the curve = 0.77 (95% confidence interval, 0.74–0.80). The risk of dementia decreased as a function of risk score from 36% to 0%. The risk score was significantly associated with cognition after a mean follow-up of 39 years in the replication sample.
Discussion: Self-report risk score predicted cognitive functioning and dementia risk 20–40 years later.
Kokoelmat
- Rinnakkaistallenteet [19207]