Risk factors for major adverse cardiovascular events after the first acute coronary syndrome
Ketonen M; Airaksinen J; Pietilä A; Havulinna AS; Koukkunen H; Salomaa V; Lehto S; Kesäniemi YA; Okkonen M; Huikuri H; Ukkola O; Mustonen J
Risk factors for major adverse cardiovascular events after the first acute coronary syndrome
Ketonen M
Airaksinen J
Pietilä A
Havulinna AS
Koukkunen H
Salomaa V
Lehto S
Kesäniemi YA
Okkonen M
Huikuri H
Ukkola O
Mustonen J
TAYLOR & FRANCIS LTD
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021093048089
https://urn.fi/URN:NBN:fi-fe2021093048089
Tiivistelmä
AimsTo evaluate risk factors for major adverse cardiac event (MACE) after the first acute coronary syndrome (ACS) and to examine the prevalence of risk factors in post-ACS patients.MethodsWe used Finnish population-based myocardial infarction register, FINAMI, data from years 1993-2011 to identify survivors of first ACS (n = 12686), who were then followed up for recurrent events and all-cause mortality for three years. Finnish FINRISK risk factor surveys were used to determine the prevalence of risk factors (smoking, hyperlipidaemia, diabetes and blood pressure) in post-ACS patients (n = 199).ResultsOf the first ACS survivors, 48.4% had MACE within three years of their primary event, 17.0% were fatal. Diabetes (p = 4.4 x 10(-7)), heart failure (HF) during the first ACS attack hospitalization (p = 6.8 x 10(-15)), higher Charlson index (p = 1.56 x 10(-19)) and older age (p = .026) were associated with elevated risk for MACE in the three-year follow-up, and revascularization (p = .0036) was associated with reduced risk. Risk factor analyses showed that 23% of ACS survivors continued smoking and cholesterol levels were still high (>5mmol/l) in 24% although 86% of the patients were taking lipid lowering medication.ConclusionDiabetes, higher Charlson index and HF are the most important risk factors of MACE after the first ACS. Cardiovascular risk factor levels were still high among survivors of first ACS.
Kokoelmat
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