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A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation

Bhosale Santosh D; Envall Tapio; Galande Sanjeev; Buchacher Tanja; Lahesmaa Riitta; Moulder Robert; Biradar Rahual; Shetty Ankitha; Tripathi Subhash Kumar; Rasool Omid; Laiho Asta; Elo Laura L; Junttila Sini

A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiation

Bhosale Santosh D
Envall Tapio
Galande Sanjeev
Buchacher Tanja
Lahesmaa Riitta
Moulder Robert
Biradar Rahual
Shetty Ankitha
Tripathi Subhash Kumar
Rasool Omid
Laiho Asta
Elo Laura L
Junttila Sini
Katso/Avaa
gkac256.pdf (5.721Mb)
Lataukset: 

OXFORD UNIV PRESS
doi:10.1093/nar/gkac256
URI
https://academic.oup.com/nar/article/50/9/4938/6574681
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022081153873
Tiivistelmä
Th17 cells are essential for protection against extracellular pathogens, but their aberrant activity can cause autoimmunity. Molecular mechanisms that dictate Th17 cell-differentiation have been extensively studied using mouse models. However, species-specific differences underscore the need to validate these findings in human. Here, we characterized the human-specific roles of three AP-1 transcription factors, FOSL1, FOSL2 and BATF, during early stages of Th17 differentiation. Our results demonstrate that FOSL1 and FOSL2 co-repress Th17 fate-specification, whereas BATF promotes the Th17 lineage. Strikingly, FOSL1 was found to play different roles in human and mouse. Genome-wide binding analysis indicated that FOSL1, FOSL2 and BATF share occupancy over regulatory regions of genes involved in Th17 lineage commitment. These AP-1 factors also share their protein interacting partners, which suggests mechanisms for their functional interplay. Our study further reveals that the genomic binding sites of FOSL1, FOSL2 and BATF harbour hundreds of autoimmune disease-linked SNPs. We show that many of these SNPs alter the ability of these transcription factors to bind DNA. Our findings thus provide critical insights into AP-1-mediated regulation of human Th17-fate and associated pathologies.
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