Brain structural alterations in autism and criminal psychopathy
Lindberg Nina; Nummenmaa Lauri; Lauerma Hannu; Noppari Tuomo; Tani Pekka; Salmi Juha; Venetjoki Niina; Sun Lihua; Salomaa Marja; Rautio Päivi; Tiihonen Jari; Putkinen Vesa; Hirvonen Jussi; Lukkarinen Lasse; Saure Emma
Brain structural alterations in autism and criminal psychopathy
Lindberg Nina
Nummenmaa Lauri
Lauerma Hannu
Noppari Tuomo
Tani Pekka
Salmi Juha
Venetjoki Niina
Sun Lihua
Salomaa Marja
Rautio Päivi
Tiihonen Jari
Putkinen Vesa
Hirvonen Jussi
Lukkarinen Lasse
Saure Emma
Elsevier
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2022091258499
https://urn.fi/URN:NBN:fi-fe2022091258499
Tiivistelmä
The goal of this study was to elucidate the anatomical brain basis of social cognition through two disorders with distinctively different phenotypes of social interaction. We compared structural MR images of 20 individuals with autism spectrum disorder (ASD), 19 violent offenders with high psychopathic traits, and 19 control participants using voxel-based morphometry (VBM). Our earlier study showed lower grey matter volume (GMV) values in the insula, frontal cortex, and sensorimotor cortex of the offender group compared to controls. In the present study, the images of the ASD group revealed lower GMV in the left precuneus, right cerebellum, and right precentral gyrus in comparison with controls. The comparison between the offender and ASD groups showed lower GMV values for the right temporal pole and left inferior frontal gyrus in the offender group. There was also an overlap of both disorders in the right pre-central cortex, showing lower GMV compared to controls. Our findings suggest structural differences between violent offenders with high psychopathy traits and ASD individuals in the frontotemporal social brain network areas, previously associated with empathy. We also provide evidence of similar abnormal structures in the motor cortex for both of these disorders, possibly related to uniting issues of social cognition.
Kokoelmat
- Rinnakkaistallenteet [19207]