68Ga-DOTA-E[c(RGDfK)]2 Positron Emission Tomography Imaging of SHARPIN-Regulated Integrin Activity in Mice
Anu K Autio; Meeri Käkelä; Emilia Peuhu; Johanna Ivaska; Sirpa Jalkanen; Olli Metsälä; Heidi Liljenbäck; Ingrid Dijkgraaf; Elina Mattila; Riikka Siitonen; Tiina Saanijoki; Anne Roivainen
68Ga-DOTA-E[c(RGDfK)]2 Positron Emission Tomography Imaging of SHARPIN-Regulated Integrin Activity in Mice
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042713122
https://urn.fi/URN:NBN:fi-fe2021042713122
Tiivistelmä
Sharpincpdm mice demonstrated increased integrin activity and vascularization in B16-F10-luc melanoma tumors, as demonstrated by RGD-based in vivo PET imaging. These data indicate that SHARPIN, a protein previously associated with increased cancer growth and metastasis, may also have important regulatory roles in controlling the tumor microenvironment.
Kokoelmat
- Rinnakkaistallenteet [19207]