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Seasonal variation in the brain μ-opioid receptor availability

Roivainen Anne; Sun Lihua; Nummenmaa Lauri; Honkaniemi Aake; Nuutila Pirjo; Scheinin Harry; Hietala Jarmo; Kalliokoski Kari; Yatkin Emrah; Tang Jing; Isojärvi Janne; Eerola Kim; Hirvonen Jussi; Savontaus Eriika; Kantonen Tatu; Virta Jenni; Rinne Juha O; Helin Semi; Karjalainen Tomi; Liljenbäck Heidi; Kaasinen Valtteri

Seasonal variation in the brain μ-opioid receptor availability

Roivainen Anne
Sun Lihua
Nummenmaa Lauri
Honkaniemi Aake
Nuutila Pirjo
Scheinin Harry
Hietala Jarmo
Kalliokoski Kari
Yatkin Emrah
Tang Jing
Isojärvi Janne
Eerola Kim
Hirvonen Jussi
Savontaus Eriika
Kantonen Tatu
Virta Jenni
Rinne Juha O
Helin Semi
Karjalainen Tomi
Liljenbäck Heidi
Kaasinen Valtteri
Katso/Avaa
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doi:10.1523/JNEUROSCI.2380-20.2020
URI
https://www.jneurosci.org/content/41/6/1265
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021042824158
Tiivistelmä

Seasonal rhythms influence emotion and sociability. The brain μ-opioid receptor (MOR) system modulates a multitude of seasonally varying socioemotional functions, but its seasonal variation remains elusive with no previously reported in vivo evidence. Here, we first conducted a cross-sectional study with previously acquired human [11C]carfentanil PET imaging data (132 male and 72 female healthy subjects) to test whether there was seasonal difference in MOR availability. We then investigated experimentally whether seasonal variation in daylength causally influences brain MOR availability in rats. Rats (six male and three female rats) underwent daylength cycle simulating seasonal changes; control animals (two male and one female rats) were kept under constant daylength. Animals were scanned repeatedly with [11C]carfentanil PET imaging. Seasonally varying daylength had an inverted U-shaped functional relationship with brain MOR availability in humans. Brain regions sensitive to daylength spanned the socio-emotional brain circuits, where MOR availability formed a spring-like peak. In rats, MOR availabilities in the brain neocortex, thalamus and striatum peaked at intermediate daylength. Varying daylength also affected the weight gain and stress hormone. We conclude that the in vivo brain MOR availability in humans and rats shows significant seasonal variation, which is predominately associated with seasonal photoperiodic variation. Given the intimate links between MOR signaling and socioemotional behavior, these results suggest that the MOR system might underlie seasonal variation in human mood and social behavior.

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