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Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors

Riikonen V. Pekka; Harila-Saari Arja H.; Puosi Riina; Ritari Niina; Arola Mikko O.; Remes Tiina M.; Lönnqvist Tuula R.I.; Rantala Heikki M.J.; Harila Marika; Ojaniemi Marja K.; Lähteenmäki Päivi M.; Hovén Emma; Sirkiä Kirsti H.; Winqvist Satu; Arikoski Pekka M.; Pohjasniemi Heli

Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors

Riikonen V. Pekka
Harila-Saari Arja H.
Puosi Riina
Ritari Niina
Arola Mikko O.
Remes Tiina M.
Lönnqvist Tuula R.I.
Rantala Heikki M.J.
Harila Marika
Ojaniemi Marja K.
Lähteenmäki Päivi M.
Hovén Emma
Sirkiä Kirsti H.
Winqvist Satu
Arikoski Pekka M.
Pohjasniemi Heli
Katso/Avaa
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OXFORD UNIV PRESS
doi:10.1093/nop/npab004
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Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021093048221
Tiivistelmä

Background. Little is known of the cognitive functions, employment, and social status in adult survivors of childhood brain tumor (BT). We aimed to determine the long-term neurocognitive profile of radiotherapy-treated adult survivors of childhood BT and the relationship between cognitive functions and employment and social status.

Methods. Neurocognitive profiles of survivors were assessed in a Finnish national cohort of 71 radiotherapy-treated survivors of childhood BT (median follow-up time: 21 years [range: 5-33 years]) using a cross-sectional design. Neurocognitive outcomes were compared to control (n = 45) and normative values. Tumor- and treatment-related data were collected from the patient files. Information on employment and social status was gathered.

Results. Survivors' (median age: 27 years [range: 16-43 years]) median verbal and performance intelligence quotient (IQ) was 90 (range: 49-121) and 87 (range: 43-119), respectively. The cognitive domains with the greatest impairment were executive functions (median z score, 3.5 SD [range: -25.0 to 1.3 SD]), and processing speed and attention (median z score, -2.5 SD [range: -24.9 to 0.5 SD]). Executive functions were associated with employment, educational level, living independently, having an intimate relationship, and having a driving license. Processing speed and attention were related to educational level, living independently, having an intimate relationship, and having a driving license. Performance IQ was associated with educational level and employment status. Working memory was associated with educational level and living independently.

Conclusions. Radiotherapy-treated adult survivors of childhood BT experience significant neurocognitive impairment, which is associated with difficulties related to employment and social status.

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