Autophagy in major human diseases
Petroni Giulia; Penninger Josef M; Juhász Gábor; Perera Rushika M; Ryan Kevin M; Kraft Claudine; Lopez-Otin Carlos; Deretic Vojo; Yuan Junying; Simon Anna Katharina; Cuervo Ana Maria; Sadoshima Junichi; Choi Augustine M K; Piacentini Mauro; Dikic Ivan; Yue Zhenyu; Baehrecke Eric H; Eskelinen Eeva-Liisa; Macleod Kay F; Reggiori Fulvio; Martinez Jennifer; Cecconi Francesco; Johansen Terje; Cadwell Ken; Simonsen Anne; Bravo-San Pedro José Manuel; Karantza Vassiliki; Zhong Qing; Santambrogio Laura; Fimia Gian Maria; Jäättelä Marja; Madeo Frank; Hansen Malene; Scorrano Luca; Green Douglas R; Elazar Zvulun; Galluzzi Lorenzo; Chu Charleen T; Gewirtz David A; Klionsky Daniel J; Choi Mary E; Codogno Patrice; Kroemer Guido; Rubinsztein David C; Tavernarakis Nektarios; Ballabio Andrea; Stolz Alexandra; Boya Patricia; Kumar Sharad; Tooze Sharon A; Yoshimori Tamotsu; Mizushima Noboru; Simon Hans-Uwe; Meléndez Alicia; Amaravadi Ravi K; Pietrocola Federico; Münz Christian; Ktistakis Nicholas T; Colombo Maria Isabel
Autophagy in major human diseases
Embo Press
Julkaisun pysyvä osoite on:
https://urn.fi/URN:NBN:fi-fe2021093048222
https://urn.fi/URN:NBN:fi-fe2021093048222
Tiivistelmä
Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models. Consistently, mutations in autophagy-related processes cause severe human pathologies. Here, we review and discuss preclinical data linking autophagy dysfunction to the pathogenesis of major human disorders including cancer as well as cardiovascular, neurodegenerative, metabolic, pulmonary, renal, infectious, musculoskeletal, and ocular disorders.
Kokoelmat
- Rinnakkaistallenteet [19207]