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Immunological and Microbiological Profiling of Cumulative Risk Score for Periodontitis

Ramin Akhi; John M. Liljestrand; Kåre Buhlin; Susanna Paju; Juha Sinisalo; Milla Pietiäinen; Timo Sorsa; Pirkko J. Pussinen; Joonas Liukkonen; Ulvi K. Gürsoy; Pratikshya Pradhan-Palikhe; Päivi Mäntylä; Aino Salminen; Sohvi Hörkkö; Eija Könönen; G. Rutger Persson

dc.contributor.authorRamin Akhi
dc.contributor.authorJohn M. Liljestrand
dc.contributor.authorKåre Buhlin
dc.contributor.authorSusanna Paju
dc.contributor.authorJuha Sinisalo
dc.contributor.authorMilla Pietiäinen
dc.contributor.authorTimo Sorsa
dc.contributor.authorPirkko J. Pussinen
dc.contributor.authorJoonas Liukkonen
dc.contributor.authorUlvi K. Gürsoy
dc.contributor.authorPratikshya Pradhan-Palikhe
dc.contributor.authorPäivi Mäntylä
dc.contributor.authorAino Salminen
dc.contributor.authorSohvi Hörkkö
dc.contributor.authorEija Könönen
dc.contributor.authorG. Rutger Persson
dc.date.accessioned2022-10-28T12:27:34Z
dc.date.available2022-10-28T12:27:34Z
dc.identifier.urihttps://www.utupub.fi/handle/10024/159641
dc.description.abstractThe cumulative risk score (CRS) is a mathematical salivary diagnostic model to define an individual's risk of having periodontitis. In order to further validate this salivary biomarker, we investigated how periodontal bacteria, lipopolysaccharide (LPS), and systemic and local host immune responses relate to CRS. Subgingival plaque, saliva, and serum samples collected from 445 individuals were used in the analyses. Plaque levels of 28 microbial species, especially those ofAggregatibacter actinomycetemcomitans,Porphyromonas gingivalis,Porphyromonas endodontalis,Prevotella intermedia, andTannerella forsythia, and serum and salivary levels of IgA and IgG against these five species were determined. Additionally, LPS activity was measured. High CRS associated strongly with all IgA/IgG antibody and LPS levels in saliva, whereas in serum the associations were not that obvious. In the final logistic regression model, the best predictors of high CRS were saliva IgA burden against the five species (OR 7.04, 95% CI 2.25-22.0), IgG burden (3.79, 1.78-8.08), LPS (2.19, 1.38-3.47), and the sum of 17 subgingival Gram-negative species (6.19, 2.10-18.3). CRS is strongly associated with microbial biomarker species of periodontitis and salivary humoral immune responses against them.
dc.language.isoen
dc.publisherMDPI
dc.titleImmunological and Microbiological Profiling of Cumulative Risk Score for Periodontitis
dc.identifier.urnURN:NBN:fi-fe2021042824660
dc.relation.volume10
dc.contributor.organizationfi=hammaslääketieteen laitos yhteiset|en=Institute of Dentistry|
dc.contributor.organization-code2607500
dc.converis.publication-id50373147
dc.converis.urlhttps://research.utu.fi/converis/portal/Publication/50373147
dc.identifier.eissn2075-4418
dc.identifier.jour-issn2075-4418
dc.okm.affiliatedauthorLiukkonen, Joonas
dc.okm.affiliatedauthorPussinen, Pirkko
dc.okm.affiliatedauthorKönönen, Eija
dc.okm.affiliatedauthorGursoy, Ulvi
dc.okm.discipline313 Dentistryen_GB
dc.okm.discipline313 Hammaslääketieteetfi_FI
dc.okm.internationalcopublicationinternational co-publication
dc.okm.internationalityInternational publication
dc.okm.typeJournal article
dc.relation.articlenumberARTN 560
dc.relation.doi10.3390/diagnostics10080560
dc.relation.ispartofjournalDiagnostics
dc.relation.issue8
dc.year.issued2020


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